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CytotecFrom: GA12L@aol.comFri May 12 02:07:25 2006
I'm sorry, but I don't understand why Cytotec is used to induce labour. Pharmacia Limited who market Cytotec here clearly state that "Cytotec is contraindicated in pregnant women and in women planning a pregnancy as it increases uterine tone and contractions in pregnancy which may cause partial or complete expulsion of the products of conception. Use in pregnancy has been associated with birth defects." Cytotec is indicated for the healing of duodenal ulcer and gastric ulcer including those induced by nonsteroidal anti-inflammatory drugs (NSAID) in arthritic patients at risk, whilst continuing their NSAID therapy. In addition, Cytotec can be used for the prophylaxis of NSAID-induced ulcers. It says nothing about using it to induce labour in fact Pharmacia says that when used in pre-menopausal women they should ensure that they have adequate contraception. The Summary of Product Characteristics (SPC) clearly says in the section Undesirable effects "A number of side effects have been reported in clinical studies or in the literature following use of misoprostol for non-approved indications. These include abnormal uterine contractions, uterine haemorrhage, retained placenta, amniotic fluid embolism, incomplete abortion and premature birth." So using Cytoec for inducing labour is a) using it for a non-approved indication and b) it CAN cause AFE. So why is it used to induce labour? Sorry, I don't understand but I'm sure one of you will enlighten me! Gail
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