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Re: Bisphosphonates From: Douglas Krell (dkrell@msn.com) Sun Apr 30 21:02:18 2006 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Joanne Bulley, MD: "Re: Bisphosphonates" Previous message: Garry E. Siegel, M.D.: "Re: Uterine rupture after VBAC**Grand Multip." In reply to: Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C.: "Re: Bisphosphonates" Next in thread: Joanne Bulley, MD: "Re: Bisphosphonates" Reply: Joanne Bulley, MD: "Re: Bisphosphonates" Forever is the right answer since when you stop, bone loss resumes in earnest,...however Fosamax has more nearly complete bone turnover suppression and theoretically there is a greater risk of osteonecrosis with this drug. People have talked about short drug free holidays with Fosamax. Long term Actonel administration has been associated with osteonecrosis although the risk is significantly reduced. Evista, on the other hand, as a SERM, works through the estrogen receptor and reestablishes a normal relationship between osteoclasts and osteoblasts and there are no such complications. -- Douglas Krell MD >From: johnprov@sympatico.ca (Dr. John Provatopoulos B.Sc. M.D.C.M. >F.R.S.C.) >Reply-To: ob-gyn-l@obgyn.net >To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net> >Subject: Re: Bisphosphonates >Date: Sat, 29 Apr 2006 09:03:14 -0500 > >At Sat, 29 Apr 2006, Jim Lie wrote: > > > >Yesterday I saw a woman who has T5 & T8 crush fractures just from >suddenly > >forward flexing. When we were discussing the options - including > >biphosphonates - she was aghast that I mentioned it - because she heard >on > >TV about how horrible this drug is --> causing osteonecrosis. I did a >google > >search and found nice lawyer sites (in USofA) asking for people to come > >forward to sue the doctors and the drug company. > > > >James Lie MBBS > >Albany > >Western Australia > > > >> >When you are treating woment with a bisphosphonate do you > >> > > >> >How long do you think she should remain on the bisphosphonates? > >> > > >> > >> Forever,-- > >> Take care, John > >> > >This is par for the course in any affluent society: never mind that most >people who get Avascular osreonecrosis also had cancer, diabetes and >peripherial vascular disease and where most likely put on on >biphospantes because they where high risk for osteoporosis and >osteonecrosis. Unfortantely estrogen is also associated with avascular >osteonecrosis so your options for preventing osteoporosis keep getting >smaller. > >-- > Take care, John Next message: Joanne Bulley, MD: "Re: Bisphosphonates" Previous message: Garry E. Siegel, M.D.: "Re: Uterine rupture after VBAC**Grand Multip." In reply to: Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C.: "Re: Bisphosphonates" Next in thread: Joanne Bulley, MD: "Re: Bisphosphonates" Reply: Joanne Bulley, MD: "Re: Bisphosphonates"

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