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Re: C sordellii and maternal death From: Joanne Bulley, MD (islesannie@yahoo.com) Sat Mar 18 12:52:22 2006 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: art fougner, md: "Re: C sordellii and maternal death" Previous message: Joanne Bulley, MD: "C sordellii and maternal death" In reply to: Joanne Bulley, MD: "C sordellii and maternal death" Next in thread: art fougner, md: "Re: C sordellii and maternal death" Reply: art fougner, md: "Re: C sordellii and maternal death" This info goes with the earlier poster who suggested it is the Mefipristone rather than the misoprostol. Now I will quit over-posting to the List! Joanne http://www.theannals.com/cgi/content/abstract/39/9/1483 Pathophysiology of Mifepristone-Induced Septic Shock Due to Clostridium sordellii Ralph P Miech, MD PhD Associate Professor Emeritus, Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown Medical School, Brown University, 174 Meeting St., Providence, RI 02912-9107, fax 401/863-1595, Ralph_Miech@brown.edu Reprints: Dr. Miech OBJECTIVE: To explain the role of mifepristone in medical abortions that results in fulminant and lethal septic shock due to Clostridium sordellii. DATA SOURCES: MEDLINE, PubMed, and Google Scholar databases were searched (1984-March 2005). Key search terms were mifepristone, RU38486, RU486, Mifeprex, medical abortion, septic shock, innate immune system, cytokines, and Clostridium sordellii. STUDY SELECTION AND DATA EXTRACTION: All articles identified from the data sources were evaluated and all information deemed relevant was included for the information related to the development of the understanding of the pathophysiology of mifepristone-induced septic shock due to C. sordellii. DATA SYNTHESIS: The mechanisms of action of mifepristone were incorporated into the pathophysiology of septic shock due to C. sordellii. Mifepristone, by blocking both progesterone and glucocorticoid receptors, interferes with the controlled release and functioning of cortisol and cytokines. Failure of physiologically controlled cortisol and cytokine responses results in an impaired innate immune system that results in disintegration of the body's defense system necessary to prevent the endometrial spread of C. sordellii infection. The abnormal cortisol and cytokine responses due to mifepristone coupled to the release of potent exotoxins and an endotoxin from C. sordellii are the major contributors to the rapid development of lethal septic shock. CONCLUSIONS: Theoretically, it appears that the mechanisms of mifepristone action favor the development of infection that leads to septic shock and intensifies the actions of multiple inflammatory cytokines, resulting in fulminant, lethal septic shock. Key Words: abortion, Clostridium sordellii, mifepristone, septic shock Published Online, July 26, 2005. http://www.theannals.com, DOI 10.1345/aph.1G189 -- Joanne Bulley, MD Keene, NH, USA "Love is indescribable and unconditional. I could tell you a thousand things that it is not, but not one that it is." — Duke Ellington, American jazz artist (1899-1974). Next message: art fougner, md: "Re: C sordellii and maternal death" Previous message: Joanne Bulley, MD: "C sordellii and maternal death" In reply to: Joanne Bulley, MD: "C sordellii and maternal death" Next in thread: art fougner, md: "Re: C sordellii and maternal death" Reply: art fougner, md: "Re: C sordellii and maternal death"

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