OB-GYN-L Messages for March, 2006: Re: NYT: Silent Struggle: A New Theory of Pregnancy

Re: NYT: Silent Struggle: A New Theory of Pregnancy

From:

Terrence.Jones@kp.org

Tue Mar 14 16:20:21 2006

As with the mythical counterpart, fetal microchimerism has more than one side (the original chimera had three parts: lion, goat, and serpent). There may well be prolongation of heterograft survival and enhanced healing, but there are also associations with autoimmune phenomena (systemic sclerosis, primary biliary cirrhosis, and autoimmune thyroid dis. Maternal-fetal microchimerism can be associated with juvenile myositis and, in Mom's with SLE, congenital heart block (from maternal cardiac myocytes) [Sarkar & Miller, Autoimmune Rev (2004), 3:454-63]. Tho it probably IS time to dismiss the idea of a Bellerophon upon Pegasus, racing to save the day from such a monster; and see the situation more like chimera's sister, the Sphinz - at times a riddler, at times a teacher. Still much to learn (Artlett (10/2005), Clin Chem Acta, 360:1-8). /tj

PS: Just wait a few years, when that Daughter is racing ahead of You down Pinball, on Her snowboard!

CONFIDENTIAL OR PRIVILEGED: This communication contains information intended only for the use of the individuals to whom it is addressed and may contain information that is privileged, confidential or exempt from other disclosure under applicable law. If you are not the intended recipient, you are notified that any disclosure, printing, copying, distribution or use of the contents is prohibited. If you have received this in error, please notify the sender immediately by telephone or by returning it by reply email and then permanently deleting the communication from your system. Thank you.

mks@sierra.net (M. Kelly Shanahan, MD, ) Sent by: ob-gyn-l@obgyn.net 03/14/2006 01:49 PM Please respond to ob-gyn-l

To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net> cc: Subject: Re: NYT: Silent Struggle: A New Theory of Pregnancy

This is a seriously cool theory -- as as a woman who has had a child, and who has had 3 miscarriages d/t antiphospholipid syndrome, I can personally vouch for the war between fetus and mom --and if my 7 year old daughter and I are any proof, it doesn't stop after birth!!

-- M. Kelly Shanahan, MD, FACOG South Lake Tahoe, CA

author, Your Over-35 Week-by-Week Pregnancy Guide available in all major bookstores and on-line at amazon.com

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As with the mythical counterpart, fetal microchimerism has more than one side (the original chimera had three parts: lion, goat, and serpent). There may well be prolongation of heterograft survival and enhanced healing, but there are also associations with autoimmune phenomena (systemic sclerosis, primary biliary cirrhosis, and autoimmune thyroid dis.  Maternal-fetal microchimerism can be associated with juvenile myositis and, in Mom's with SLE, congenital heart block (from maternal cardiac myocytes) [Sarkar & Miller, Autoimmune Rev (2004), 3:454-63]. Tho it probably IS time to dismiss the idea of a Bellerophon upon Pegasus, racing to save the day from such a monster; and see the situation more like chimera's sister, the Sphinz - at times a riddler, at times a teacher. Still much to learn (Artlett (10/2005), Clin Chem Acta, 360:1-8).   /tj PS: Just wait a few years, when that Daughter is racing ahead of You down Pinball, on Her snowboard! CONFIDENTIAL OR PRIVILEGED:  This communication contains information intended only for the use of the individuals to whom it is addressed and may contain information that is privileged, confidential or exempt from other disclosure under applicable law.  If you are not the intended recipient, you are notified that any disclosure, printing, copying, distribution or use of the contents is prohibited.  If you have received this in error, please notify the sender immediately by telephone or by returning it by reply email and then permanently deleting the communication from your system. Thank you. <table width0%> <tr valign=top> <td> <td>mks@sierra.net (M. Kelly Shanahan, MD, ) Sent by: ob-gyn-l@obgyn.net 03/14/2006 01:49 PM Please respond to ob-gyn-l <td>                To:        Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net>         cc:                 Subject:        Re: NYT:  Silent Struggle: A New Theory of Pregnancy</table> This is a seriously cool theory -- as as a woman who has had a child, and who has had 3 miscarriages d/t antiphospholipid syndrome, I can personally vouch for the war between fetus and mom --and if my 7 year old daughter and I are any proof, it doesn't stop after birth!! -- M. Kelly Shanahan, MD, FACOG South Lake Tahoe, CA author, Your Over-35 Week-by-Week Pregnancy Guide available in all major bookstores and on-line at amazon.com

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