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Re: Ortho Evra From: babycatchers@aol.com Tue Feb 28 08:13:42 2006 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: GA12L@aol.com: "Re: Ortho Evra" Previous message: Gerald P. Rodríguez: "Re: Our friends, the ureters" In reply to: Larry Glazerman: "Re: Ortho Evra" Excuse my ignorance- could you state what 2X RR VTE stands for, please? -----Original Message----- From: Larry Glazerman <l.glazerman@rcn.com> To: Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net> Sent: Mon, 27 Feb 2006 21:38:14 -0600 Subject: Re: Ortho Evra I'm on Ortho's speaker's bureau. The bottom line is that despite the new info about a 60% higher average blood level with Evra than with OCs, there is NO data confirming an increased risk of any side effect. In conjunction with the FDA, Ortho has sponsored several epidemiologic studies. One is now in press, and, to summarize, shows no difference in VTE between Evra and a 35 mcg pill. A second study, equally well done, not yet published, apparently shows an increase from 1-2/10,000 VTE with OC to 2-4 /10,000 with Evra. This is a RR of ~2, but an absolute risk of 1-2/10,000 patients (very low, IMHO). Also, it should be noted that other current contraceptives have significant warnings in their package inserts: Seasonale - significantly higher bleeding rates Yasmin - ?problems with K+ due to spironolactone like effect NuvaRing - 2X RR VTE The fact remains that all of these hormonal contraceptives are very safe, probably none any safer or more dangerous significantly than any other, and ALL much safer than pregnancy!!!!!! Waiting for the flames :) -- Larry R. Glazerman, MD 610-402-0161 l.glazerman@rcn.com -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Garry E. Siegel, M.D. Sent: Monday, February 27, 2006 9:54 PM To: Multiple recipients of list OB-GYN-L Subject: Gyn: Ortho Evra The nice Ortho rep brought in a lunch today to talk about the bad rap Evra has gotten, yet it is (according to him) the most prescribed hormonal contraceptive in the US. Has anyone changed their habits regarding this since the poop has hit the fan, i.e. the FDA made Ortho change the labeling and some brouhaha about strokes? Has anyone seen the science on it? Garry -- Garry E. Siegel, M.D. Private Practice Roswell, GA Next message: GA12L@aol.com: "Re: Ortho Evra" Previous message: Gerald P. Rodríguez: "Re: Our friends, the ureters" In reply to: Larry Glazerman: "Re: Ortho Evra"

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