Re: Ortho Evra
From: Joe (forcep@intercom.net)
Tue Feb 28 05:18:35 2006
Larry: Thanks for the info. No one wishes to discuss probability of risk
on national TY. Its not sexy. In 1961 as you recall Enovid was 10 mgm.
Have you ever wondered why it took 40 years to get to 35 mcg?? I have
trouble with not believing the lower doses were known and simply held
back due to marketing issues. Joe C
Larry Glazerman wrote:
> I'm on Ortho's speaker's bureau. The bottom line is that despite the new
> info about a 60% higher average blood level with Evra than with OCs, there
> is NO data confirming an increased risk of any side effect.
>
> In conjunction with the FDA, Ortho has sponsored several epidemiologic
> studies. One is now in press, and, to summarize, shows no difference in VTE
> between Evra and a 35 mcg pill. A second study, equally well done, not yet
> published, apparently shows an increase from 1-2/10,000 VTE with OC to 2-4
> /10,000 with Evra. This is a RR of ~2, but an absolute risk of 1-2/10,000
> patients (very low, IMHO). Also, it should be noted that other current
> contraceptives have significant warnings in their package inserts:
>
> Seasonale - significantly higher bleeding rates
> Yasmin - ?problems with K+ due to spironolactone like effect
> NuvaRing - 2X RR VTE
>
> The fact remains that all of these hormonal contraceptives are very safe,
> probably none any safer or more dangerous significantly than any other, and
> ALL much safer than pregnancy!!!!!!
>
> Waiting for the flames :)
>
> Larry R. Glazerman, MD
>
> 610-402-0161
> l.glazerman@rcn.com
>
> -----Original Message-----
> From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Garry E.
> Siegel, M.D.
> Sent: Monday, February 27, 2006 9:54 PM
> To: Multiple recipients of list OB-GYN-L
> Subject: Gyn: Ortho Evra
>
> The nice Ortho rep brought in a lunch today to talk about the bad rap
> Evra has gotten, yet it is (according to him) the most prescribed
> hormonal contraceptive in the US.
>
> Has anyone changed their habits regarding this since the poop has hit
> the fan, i.e. the FDA made Ortho change the labeling and some brouhaha
> about strokes? Has anyone seen the science on it?
>
> Garry
>
> --
> Garry E. Siegel, M.D.
> Private Practice
> Roswell, GA
>
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