Re: Oligohydramnios, dolicocephaly and elevated AFP

From: Jim Wang (jimwangmd@yahoo.com)
Thu Jun 23 11:11:28 2005


Dan,

Once again, thank you for your sincere response.

Yes, we will terminate Down's, trisomy 18 and trisomy 21. However, elevated AFAFP & AChE, if US continued to show normal anatomy and fetal movement, we will not choose to terminate.

The reason I may seem "fixated" at a numeric risk estimate is that if the chance of having complications from amnio is, say 5%; but, the probability of finding chromosomal abnormality (maternal serum AFP screening is positive for spina bifida and negative for Downs, etc...) is say, 2% based on negative family history, etc... Then, we would deem the risk too high and decline amnio-infusion/centesis. If the estimated risk is even higher (say, 30%) and greatly exceeds the probability of finding a reason to terminate, such procedure- no matter how useful the information may be- is clearly an unfavorable gamble. This is why I feel quantifying the risks is important in making this difficult decision. Thanks.

Regards, Jim Wang

At Thu, 23 Jun 2005, R. Daniel Braun wrote: >
>The real question is not the absolute risk of various procedures. The rea
>question is what will you do with the results? i.e. will you terminate a
>Down's? a trisomy 18? a trisomy21? an elevated AFAFP & AChE ???? or not? i
>not? then just hang in there with much anxiety for the next 2-5 months unt l
>you get the answer by delivery. Otherwise get the procedure done and act o
>the results.
> Just MHO
>Dan

--
Jim Wang, MD




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