Re: immunoglobin theraphy for recurrent abortions
From: Garry E. Siegel, M.D. (dean@thehuffpeople.net)
Sun Apr 10 21:37:30 2005
..
When I was a fellow, one of our faculty had a few patients where he injected
(transfused) WBC from the putative father (of course, checked for blood type
compatabilty) into the pregnant woman. There was a write up about it in a
popular (i.e., aimed at the general public) science magazine, "Discovery" or
"Discovery Science" or something like that, back in 1986 or 1987. His name was
Amankwah.
Dean Huffman
- - - -
Quoting "art fougner, md" <evsono@pipeline.com>:
> >From Cochrane ...
>
> Author
> Scott, JR
> Title
> Immunotherapy for recurrent miscarriage.
> Source
> Cochrane Database of Systematic Reviews. 1, 2005.
> Abstract
> Background:
>
> Immunologic aberrations might be the cause of recurrent early pregnancy
> loss in some women.
>
> Objectives:
>
> The objective of this review was to assess the effects of leukocyte
> immunisation or other immunologic treatments such as intravenous immune
> globulin (IVIG) on the live birth rate in women with previous
> unexplained recurrent miscarriages.
>
> Search strategy:
>
> The Cochrane Pregnancy and Childbirth Group trials register was searched
> (September 2002). Individual patient data were obtained from the
> American Society for Reproductive Immunology.
>
> Selection criteria:
>
> Randomised trials of immunotherapy in women with three or more prior
> miscarriages and no more than one live birth; all recognised
> non-immunologic causes ruled out and no simultaneous treatment
> intervention.
>
> Data collection and analysis:
>
> Eligibility and trial quality were assessed by one reviewer.
>
> Main results:
>
> Nineteen trials of high quality were included. The various forms of
> immunotherapy did not show significant differences between treatment and
> control groups in terms of subsequent live births: paternal cell
> immunisation (11 trials, 596 women), odds ratio (OR) 1.05, 95%
> confidence intervals (CI) 0.75 to 1.47; third party donor cell
> immunization (3 trials, 156 women), OR 1.39, 95% CI 0.68 to 2.82;
> trophoblast membrane infusion (1 trial, 37 women), OR 0.40, 95% CI 0.11
> to 1.45; intravenous immune globulin (IVIG), OR 0.98, 95% CI 0.61 to
> 1.58.
>
> Conclusions:
>
> Paternal cell immunization, third party donor leukocytes, trophoblast
> membranes, and intravenous immune globulin provide no significant
> beneficial effect over placebo in preventing further miscarriages.
>
> art
>
> At Sat, 9 Apr 2005, Myer S. Bornstein wrote:
> >
> >Does any one have any information or ideas about immunoglobulin therapy in
> >recurrent abortions? Is any one using it or is it still experimental. I
> >have just seen a patient that was recommend this for multiple spontaneous
> >abortions.
> >Thanks
> >Myer
> >
> >--
> >Myer S. Bornstein, MD, MMM, FACOG, FACPE
> >
>
> --
> art fougner, md
>
> "If you don't know where you are going, you will wind up somewhere else."
> Lawrence Peter Berra
>
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