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Re: MethotrexateFrom: Julio Arellano (arellano@netverk.com.ar)Fri Mar 18 19:23:19 2005
Dear colleagues: We´ve used methotrexate as a conservative option in two cases of ectopic pregnancy, in cervical and cornual (interstitial) location. In both cases the dose was 1 mg/kg/day, and it shows as a succesfully alternative to surgical treatment, with a mild abdominal pain and minimal vaginal bleeding in the cervical. Anyway, methotrexate interferes with DNA synthesis and thus is teratogenic, so I´m not sure if an 'threshold' or 'safe' dose can be determined. Julio C Arellano, MD La Plata. Bs As Argentina. -------Mensaje original------- De: R. Daniel Braun Fecha: 03/16/05 14:55:09 Para: Multiple recipients of list OB-GYN-L Asunto: Re: Methotrexate But in much HIGHER Doses. Dan On Wed, 16 Mar 2005 09:53:30 -0600, alejandro.morales@cecla.com <alejandro.morales@cecla.com> wrote: > > Remember that methotrexate has been used in ectopic pregnancy as a medical > (non surgical) option. > > ALEJANDRO MORALES DEL OLMO MD > > RreyANP@aol.com > Enviado por: > ob-gyn-l@obgyn.n > et > 16/03/2005 12:11 Para: > a.m. Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net> > Por favor, > responda a > ob-gyn-l cc: > > Asunto: > Methotrexate > > Hi all, > What's been your experience with Methotrexate in early pregnancy. I have a > patient who was taking Methotrexate for rheumatoid arthritis. Her last dose > (15mg) was Feb 12 and she found out she was unexpectedly pregnant. > > Your thoughts are appreciated. > > Abby, NP > -- R. Daniel Braun Kinky for Governor
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