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Re: Methotrexate From: art fougner, md (evsono@pipeline.com) Wed Mar 16 10:13:12 2005 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: R. Daniel Braun: "Re: Methotrexate" Previous message: art fougner, md: "Re: Ultrasound as part of the normal exam" In reply to: alejandro.morales@cecla.com: "Re: Methotrexate" Next in thread: R. Daniel Braun: "Re: Methotrexate" Althought MTX and other anti-folates have been linked with limb-reduction and other abnormalities, this article is encouraging - J Rheumatol. 2004 Dec;31(12):2360-5. Related Articles, Links Low dose methotrexate in the first trimester of pregnancy: results of a French collaborative study. Lewden B, Vial T, Elefant E, Nelva A, Carlier P, Descotes J; French Network of Regional Pharmacovigilance Centers. Centre Antipoison, Centre de Pharmacovigilance, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France. OBJECTIVE: To assess the risk of major malformations in pregnant women with chronic inflammatory disorders treated with low dose methotrexate (MTX) during the first trimester of pregnancy. Secondary outcomes included the rate of miscarriage, birth weight, and gestational age at delivery. METHODS: Data from the French network of 31 pharmacovigilance centers and 2 teratology information services were analyzed. The outcome of pregnancy was prospectively assessed in women exposed during the first trimester of pregnancy. Data on maternal history and drug exposure were collected at the initial inquiry, and on the outcome of pregnancy at followup. RESULTS: Twenty-eight cases were available for analysis. MTX exposure ended before 8 weeks of gestation in 26 patients. Miscarriages occurred in 4 patients and 5 had elective termination of pregnancy. There were 19 live births, among whom 3 were premature. Birth weights in full-term children were within the expected range. One child exposed until 8.5 weeks of gestation had only minor anomalies (metatarsus varus and eyelid angioma). CONCLUSION: Although no definitive conclusion can be drawn, our results and the analysis of the literature support the conclusion that no strong teratogenic risk is associated with low dose MTX provided that the drug is discontinued as early as possible in pregnant women. art At Wed, 16 Mar 2005, alejandro.morales@cecla.com wrote: > >Remember that methotrexate has been used in ectopic pregnancy as a medical >(non surgical) option. > >ALEJANDRO MORALES DEL OLMO MD > > RreyANP@aol.com > Enviado por: > ob-gyn-l@obgyn.n > et > 16/03/2005 12:11 Para: > a.m. Multiple recipients of list OB-GYN-L <ob-gyn-l@dns.obgyn.net> > Por favor, > responda a > ob-gyn-l cc: > > Asunto: > Methotrexate > >Hi all, >What's been your experience with Methotrexate in early pregnancy. I have a >patient who was taking Methotrexate for rheumatoid arthritis. Her last dose >(15mg) was Feb 12 and she found out she was unexpectedly pregnant. > >Your thoughts are appreciated. > >Abby, NP -- art fougner, md "If you don't know where you are going, you will wind up somewhere else." Lawrence Peter Berra Next message: R. Daniel Braun: "Re: Methotrexate" Previous message: art fougner, md: "Re: Ultrasound as part of the normal exam" In reply to: alejandro.morales@cecla.com: "Re: Methotrexate" Next in thread: R. Daniel Braun: "Re: Methotrexate"

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