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Re: cent CaseFrom: Braun, R. Daniel (rbraun@iupui.edu)Fri Jan 28 04:38:30 2005
That's what I love about this list. Ask and ye shall receive. Thanks, Ef. Dan R. Daniel Braun, MD "If everyone likes you, you're doing something wrong." Kinky Friedman I believe a self-righteous liberal or conservative with a cause is more dangerous than a Hell's Angel with an attitude. Andy Rooney -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Efrain Ramirez Sent: Thursday, January 27, 2005 2:53 PM To: Multiple recipients of list OB-GYN-L Subject: Re: cent Case Level of maternal IgG anti-group B streptococcus type III antibody correlated with protection of neonates against early-onset disease caused by this pathogen. J Infect Dis 2004 Sep 1;190(5):928-34 (ISSN: 0022-1899) Lin FY; Weisman LE; Azimi PH; Philips JB; Clark P; Regan J; Rhoads GG; Frasch CE; Gray BM; Troendle J; Brenner RA; Moyer P; Clemens JD National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7510, USA. link@exchange.nih.gov. ------------------------------------------------------------------------ The present study estimates the level of maternal immunoglobulin (Ig) G ------------------------------------------------------------------------ anti-group B streptococcus (GBS) type III required to protect neonates -- ------------------------------------------------------------------------ against early-onset disease (EOD) caused by this pathogen. Levels of maternal serum IgG anti-GBS type III, measured by enzyme-linked immunosorbent assay, in 26 case patients (neonates with EOD caused by GBS type III) and 143 matched control subjects (neonates colonized by GBS type III who did not develop EOD) of > or = 34 weeks gestation were compared. The probability of EOD decreased with increasing levels of maternal IgG anti-GBS type III (P = .01). Neonates whose mothers had > or = 10 microg/mL IgG anti-GBS type III had a 91% lower risk for EOD, compared with those whose mothers had levels of < 2 microg/mL. A vaccine that induces IgG anti-GBS type III levels of > or = 10 microg/mL in mothers can be predicted to offer a significant degree of protection against EOD caused by this pathogen. At Thu, 27 Jan 2005, Braun, R. Daniel wrote: > >That happens in the vast majority of babies that are colonized. Out of >every 400 colonized mothers there is only one baby with a GBBS >"infection", even though most are colonized. IMHO, research needs to be |
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