Re: GYN: Mouse antibodies/HCG

From: Garry E. Siegel, M.D. (garrys@mindspring.com)
Wed Jul 28 19:55:03 2004


One more thing--I've seen a few case reports (malpractice ones) about giving chemo with an incorrect diagnosis of a trophoblastic tumor. While it wasn't a simple shot of methotrexate, I'm not ready to administer until this is fully investigated.

Garry

Robert:

No doubt an abnormal pregnancy IF a pregnancy.

I spoke with local hospital lab tech last night--she was familiar with this and suggests a UCG.

This AM, UCG negative (HCG was 150 2 days ago, stable for 3 weeks).

Hospital #1 lab guy suggests using their HCG machine--methodology to reduce cross reactivity. Hospital #2 lab girl says the same on their machine.

Reference lab guy called and hasn't a clue, but the medical director is to call. Their catalog of tests offers a mouse antibody test.

Once I hear from the lab doc, I'll likely send off the mouse test AND a hospital HCG.

Garry

At Wed, 28 Jul 2004, RModugno@aol.com wrote: >
>In a message dated 7/27/2004 6:07:01 PM Eastern Standard Time,
>garrys@mindspring.com writes:
>I have inherited a case to deal with while my partner is on vacation;
>details sketchy.
>
>32 YO P0 with positive UCG 7/8 in office, 7/8 spotted, HCG 150 approx.,
>progesterone 1.7. Had "menses" for a few days, and now is not bleeding,
>asymptomatic, and still is running HCGs around 144 to 150 (all in the
>same lab).
>
>While I don't know this for sure, I have no doubt that she has been
>examined and it was benign. Ultrasound 7/23--empty uterus, normal
>adnexa, trace free fluid.
>
>Is this a case where mouse antibodies might help?
>Use a different lab (waiting to talk to the lab supervisor in one
>hospital about this)?
>Could this be a chronic ectopic?
>Should I empty her uterus and go from there?
>
>The lab tech today (after 5 PM)at the hospital immediately suggested
>doing a urine pregnancy test, and that is planned tomorrow. However, I
>didn't realize that she had been positive in the UCG on 7/8.
>
>Any thoughts?
>
>Garry
>Abnormal pregnancy. A shot of methotrexate couldn't hoit!
>Emptying an 'empty" uterus will complicate things and if it's empty - then
>what?
>
>Robert Modugno MD MBA FACOG
>Marietta, GA
>http://www.novaobgyn.yourmd.com

--
Garry E. Siegel, M.D.
Private Practice
Roswell, GA




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