Re: Misoprostol for Incomplete Miscarriage
From: art fougner, md (evsono@pipeline.com)
Mon May 3 12:12:57 2004
sorry Lynn -
one dose vs two doses 4 hrs apart.
At Mon, 3 May 2004, Lynn D. Montgomery, M.D. wrote:
>
>Art,
>Did the double dose group get 1200 mcg initially or did they space out
>two 600 mcg doses?
>Lynn
>
>--
>Lynn D. Montgomery, M.D.
>Maternal-Fetal Medicine, OB/GYN
>Rocky Mountain Women's Health
>2835 Fort Missoula Rd., Suite 303
>Missoula, Montana, 59804
>406-549-0978
>fax 406-549-0987
>e-mail: apgar10@montanadsl.net
>
>-----Original Message-----
>From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of art
>fougner, md
>Sent: Monday, May 03, 2004 5:57 AM
>To: Multiple recipients of list OB-GYN-L
>Subject: GYN: Misoprostol for Incomplete Miscarriage
>
>Two Regimens of Misoprostol for Treatment of Incomplete Abortion Kelly
>Blanchard, MSc*, Surasak Taneepanichskul, MD, MPH, Orawan Kiriwat, MD,
>Korakot Sirimai, MD, Nucharee Svirirojana, MSc*, Nqobile Mavimbela* and
>Beverly Winikoff, MD, MPH*
>>From the *Population Council, Johannesburg, South Africa; Bangkok,
>Thailand; and New York, New York; the Department of Obstetrics and
>Gynecology, Faculty of Medicine, Chulalongkorn Hospital, Chulalongkorn
>University, Bangkok, Thailand; and the Department of Obstetrics and
>Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University,
>Bangkok, Thailand.
>
>Address reprint requests to: Kelly Blanchard, P.O. Box 1985, Parklands
>2121, South Africa; e-mail: kblanchard@ibisreproductivehealth.org.
>
>OBJECTIVES: Misoprostol shows promise for treatment of incomplete
>abortion. We evaluated 2 simple misoprostol regimens to estimate
>whether they were effective in treating incomplete abortion.
>
>METHODS: A total of 169 women was randomly assigned to either a single
>or double dose of 600 µg misoprostol. The women, who would have
>received a surgical evacuation of the uterus for incomplete abortion,
>were patients at 2 hospitals in Bangkok, Thailand. The 2 groups of
>women were compared for success of treatment (no need for surgical
>evacuation), side effects, and acceptability.
>
>RESULTS: Sixty-six percent of women in the single-dose group and 70% of
>women in the double-dose group had complete abortions with misoprostol.
>More than 90% of women in the single- and double-dose groups reported
>that the side effects were tolerable; frequency of side effects was
>similar between the 2 groups. Women found the treatment acceptable.
>Approximately 90% of women in both groups would recommend the treatment
>to a friend. Acceptability and efficacy were different at the 2
>participating clinics.
>
>CONCLUSION: Misoprostol is an effective treatment for incomplete
>abortion. Simple regimens may be as effective as more complicated ones
>and a single dose of 600 µg should be further evaluated in larger
>trials.
>
>LEVEL OF EVIDENCE: I
>
>Obstetrics & Gynecology 2004;103:860-865
>
>--
>art fougner, md
>ich bin ein New Yorker
>
--
art fougner, md
ich bin ein New Yorker
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