--
Lynn D. Montgomery, M.D.
Maternal-Fetal Medicine, OB/GYN
Rocky Mountain Women's Health
2835 Fort Missoula Rd., Suite 303
Missoula, Montana, 59804
406-549-0978
fax 406-549-0987
e-mail: apgar10@montanadsl.net
-----Original Message-----
From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of art
fougner, md
Sent: Monday, May 03, 2004 5:57 AM
To: Multiple recipients of list OB-GYN-L
Subject: GYN: Misoprostol for Incomplete Miscarriage
Two Regimens of Misoprostol for Treatment of Incomplete Abortion Kelly
Blanchard, MSc*, Surasak Taneepanichskul, MD, MPH, Orawan Kiriwat, MD,
Korakot Sirimai, MD, Nucharee Svirirojana, MSc*, Nqobile Mavimbela* and
Beverly Winikoff, MD, MPH*
>From the *Population Council, Johannesburg, South Africa; Bangkok,
Thailand; and New York, New York; the Department of Obstetrics and
Gynecology, Faculty of Medicine, Chulalongkorn Hospital, Chulalongkorn
University, Bangkok, Thailand; and the Department of Obstetrics and
Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University,
Bangkok, Thailand.
Address reprint requests to: Kelly Blanchard, P.O. Box 1985, Parklands
2121, South Africa; e-mail: kblanchard@ibisreproductivehealth.org.
OBJECTIVES: Misoprostol shows promise for treatment of incomplete
abortion. We evaluated 2 simple misoprostol regimens to estimate
whether they were effective in treating incomplete abortion.
METHODS: A total of 169 women was randomly assigned to either a single
or double dose of 600 µg misoprostol. The women, who would have
received a surgical evacuation of the uterus for incomplete abortion,
were patients at 2 hospitals in Bangkok, Thailand. The 2 groups of
women were compared for success of treatment (no need for surgical
evacuation), side effects, and acceptability.
RESULTS: Sixty-six percent of women in the single-dose group and 70% of
women in the double-dose group had complete abortions with misoprostol.
More than 90% of women in the single- and double-dose groups reported
that the side effects were tolerable; frequency of side effects was
similar between the 2 groups. Women found the treatment acceptable.
Approximately 90% of women in both groups would recommend the treatment
to a friend. Acceptability and efficacy were different at the 2
participating clinics.
CONCLUSION: Misoprostol is an effective treatment for incomplete
abortion. Simple regimens may be as effective as more complicated ones
and a single dose of 600 µg should be further evaluated in larger
trials.
LEVEL OF EVIDENCE: I
Obstetrics & Gynecology 2004;103:860-865
--
art fougner, md
ich bin ein New Yorker
