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Re: I'm back too and PCR testingFrom: Dr. Ainsworth (ainsron@sbcglobal.net)Tue Dec 23 08:06:38 2003
The HerpeSelect-1 (ELISA) is 96% sensitive and 97% specific. The HerpeSelect-2 is 99% sensitive and 98% specific. That is in comparison to the Western blot test. They take 3 wks to seroconvert, compared to a delay in the western blot of 6 wks to 3 months. Seroconversion, of course, can be useful in distinguishing a primary from a recurrent lesion. Although cultures are the preferred method to detect virus, the problem with viral culture is that they have up to 50% false negative rates because the virus is only shed from a recurrent lesion for about 2-3 days and require a week to read. Modified culture techniques (ELVIS) provide more rapid turnaround, but don't separate HSV-1 from HSV-2. [Clinical challenges in primary care. AMA. 2002.]
>Interesting approach. Do you know if there is much cross reactivity
>>> Charlie Chambers
>>>
>>>
>--
>cchamber@alumni.rice.edu
>
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