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Re: GYN: Osteoporosis/Osteopenia in pre-menopausal womenFrom: Douglas Krell (dkrell@msn.com)Sun Aug 3 16:59:51 2003
Dr. Ramirez wrote: - I won't quarrel with someone giving Fosamax 35 mgs weekly.... I would be very concerned about giving Alendronate to a young woman. First of all it has a 10 year half life. It's a molecule that is deposited in the osteoid matrix that kills osteoclasts resulting in a nearly 90% suppression of bone resorption. Ultimately if you halt resorption too much you also prevent new bone deposition. BMD testing is an imperfect measure of bone quality... Using Fosamax just to light up the scan a bit, may not tell you anything about bone quality and or osteoporosis related fracture risk reduction 20 or 30 or 40 years later. That brings up another point...no bone biopsy data past 10 years. And no data on giving this stuff to young women. Without an underlying medical cause for bone loss...I agree that a thorough workup is necessary if you are entertaining therapy, I simply encourage diet, exercise, Calcium.
-- Douglas Krell MD FACOG
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