Re: F/U 15 Week Echo Twin A ,NT4.3 ;Twin B NT 1.6, nl chromo

From: Charlie Chambers (cchamber@gorge.net)
Fri May 30 00:21:10 2003


Is this question in retrospect, i.e. that is how the karyotypes are known or was amnio done? Nuchal translucency has been a marker for risk for aneuploidy, therefore, if karyotype is normal than forget about the NT. With that much discrepancy, I wonder how well the NT was performed? Was this from a center with much experience? Real easy to accidentally measure distance to the amnion. Too my knowledge suggesting adverse outcomes with increased NT and normal karyotype. Anyone, please correct me if I'm, wrong. NT is still a screening tool, and probably more effective to suggest decreased risk. As a screening tool, normal karyotype with abnormal NT is not unheard of. On Thursday, May 29, 2003, at 09:08 AM, Patricia Sabb wrote:

> 35 yo physician with lower(closer to cervix) Twin A 46XX, NT 4.3; Twin
> B
> 46XY, NT 1.6. Echo at 14 wk 6 day showed no obvious cardiac
> abnormalities.
>
> Risk of abnormality not detectable on US prenatally? Is it really 10%?
>
> If selective reduction of lower twin with increased nuchal, risk to
> other twin?
>
> Maternal factors influence NT? Since twins with discordant NT, more
> likely to signify abnormality?
>
> How can you explain increased NT at 11-14 wk with a subsequent normal
> outcome? Why was it elevated originally?
>
> Patient is naturally pessimistic (side effect of being a doctor and
> seeing the worst) and is having a hard time deciding next course of
> action.
>
> Thank you for your help.
>
> --
> Patricia Sabb, MD
>
************************************************************************ * Charlie Chambers

--
Hood River, OR
cchamber@alumni.rice.edu

"No matter where you go... there you are." Dr. Buckaroo Banzai ************************************************************************





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