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Re: Change of management?From: Jim Christman (jcleb@earthlink.net)Sat May 3 13:16:30 2003
We have a patient very similar to yours. She came to us in early pregnancy with LGSIL followed for about 2 yrs after confirming colposcopy/bx (done at an outside practice - conventional Paps). Our Thin Prep Pap was returned HGSIL. F/U colposcopy by myself returned CIN 3, possible CIS. Now we are staring at a cone biopsy in pregnancy - not a pleasant undertaking. The presence of high risk HPV DNA makes me a bit nervous, especially in a pt. with documented abn Paps for 4 yrs. I would tend to favor eradication of this lesion with a repeat colposcopy and gentle LEEP. I know that might not eradicate the virus from her system, but at least it gets you back to square 1 with regards to cervical dysplastic cells. We have not seen infertility or cervical incompetence as a complication, although I suppose it must be discussed with the pt. I also strongly encourage pts. that smoke to stop immediately, as I think this is a serious risk factor in inhibiting the body's immune response to HPV.
-- Jim Christman, MD, FACOG Lebanon, PA
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