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Re: Hormone may help prevent premature births From: art fougner, md (evsono@pipeline.com) Fri Feb 7 10:59:30 2003 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Braun, R. Daniel: "Re: Hormone may help prevent premature births" Previous message: mark decker: "Re: Laying our lives bare" In reply to: Braun, R. Daniel: "Re: Hormone may help prevent premature births" Next in thread: Braun, R. Daniel: "Re: Hormone may help prevent premature births" worthless in threatened miscarriage save for those with luteal phase defect - Johnson studies with dela lutin suggested efficacy for prevention of preterm delivery if given from 16 wks onward. Obstet Gynecol 1979 Oct;54(4):412-8 Related Articles, Links High-risk prematurity--progestin treatment and steroid studies. Johnson JW, Lee PA, Zachary AS, Calhoun S, Migeon CJ. Studies have been undertaken regarding the efficacy and modus operandi of 17 alpha-hydroxyprogesterone caproate (17 alpha-OHP-C) in preventing premature labor in high-risk patients. In a total of 70 patients, the treated patient population had a prematurity rate (12.8%) and a perinatal mortality rate (5%) which were significantly lower than those of the total placebo or untreated patient group (40.9 and 25%, respectively). In addition, sequential plasma steroid values were determined in 21 patients, 10 of whom delivered prematurely. The results indicate that low plasma progesterone (P) and 17 alpha-hydroxyprogesterone (17 alpha-OHP) levels precede the onset of preterm labor by weeks. Successful treatment with 17 alpha-OHP-C was characterized by elevated P levels. Plasma estradiol (E2) and cortisol (C) values did not vary with time of delivery or treatment. These findings support the progesterone block theory as an important mechanism affecting preterm delivery in this high-risk population. art At Fri, 7 Feb 2003, Braun, R. Daniel wrote: > >I don't remember that. When was it? > >Dan > >-----Original Message----- >From: DoctorJoe@aol.com [mailto:DoctorJoe@aol.com] >Sent: Thursday, February 06, 2003 7:04 PM >To: Multiple recipients of list OB-GYN-L >Subject: Re: Hormone may help prevent premature births > >In a message dated 2/6/03 16:38:51, rbraun@iupui.edu writes: > >There were 2 studies by Johnson out of Hopkins in the 60's and 70's that >showed the same thing using Delalutin. Nobody ever jumped on that. Why >the big deal now?? > >Wellllllll... I don't want to get cantankerous, but on this very list, >maybe a couple of years ago, people almost unanimously ROUNDLY CONDEMNED >progesterone as worthless in prematurity. So, if the doctors don't >believe it works, then nobody will jump on it, right? Because nobody >will use it (or those that do will be condemned and face some >liability/vulnerability). > >So what's the problem? > >Joe P. > >hehe -- art fougner, md ich bin ein New Yorker Next message: Braun, R. Daniel: "Re: Hormone may help prevent premature births" Previous message: mark decker: "Re: Laying our lives bare" In reply to: Braun, R. Daniel: "Re: Hormone may help prevent premature births" Next in thread: Braun, R. Daniel: "Re: Hormone may help prevent premature births"

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