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Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic From: Braun, R. Daniel (rbraun@iupui.edu) Tue Oct 22 06:28:38 2002 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Previous message: Garry E. Siegel, M.D.: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Maybe in reply to: Dean Huffman: "MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Next in thread: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Myer Bornstein: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" I have been trying to get it deleted from our armamentarium since the study showing that Nifedipine was more effective and had fewer side effects. Dan -----Original Message----- From: Dean Huffman [mailto:perinatl@hotmail.com] Sent: Monday, October 21, 2002 9:29 PM To: Multiple recipients of list OB-GYN-L Subject: MgSO4 -- Magnesium Sulfate -- As A Tocolytic .. Does anybody have any comments about the recent article in the Grey Journal? Do you still think MgSO4 should be used as a tocolytic? It should be noted that in the article, none of the adverse effects of MgSO4 reached statistical significance, but there was definately a trend. -- Am J Obstet Gynecol 2002 Jun;186(6):1111-8 Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Mittendorf R, Dambrosia J, Pryde PG, Lee KS, Gianopoulos JG, Besinger RE, Tomich PG. Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA. rmitten@lumc.edu OBJECTIVE: The purpose of this study was to determine whether the use of antenatal magnesium sulfate prevents adverse outcomes (neonatal intraventricular hemorrhage, periventricular leucomalacia, death, and cerebral palsy). STUDY DESIGN: In a controlled trial, we randomized mothers in preterm labor to magnesium sulfate, "other" tocolytic, or placebo. At delivery, umbilical cord blood was collected for the later determination of serum ionized magnesium levels. Neonatal cranial ultrasound scans were obtained periodically for the diagnosis of intraventricular hemorrhage and periventricular leucomalacia. Among survivors, the diagnosis of cerebral palsy was made at age 18 months. RESULTS: Children with adverse outcomes had higher umbilical cord magnesium levels at delivery. In regression models that controlled for confounders, which included very low birth weight, magnesium remained a significant risk factor (adjusted odds ratio, 3.7; 95% CI, 1.1-11.9; P =.03). CONCLUSION: Contrary to original hypotheses, this randomized trial found that the use of antenatal magnesium sulfate was associated with worse, not better, perinatal outcome in a dose-response fashion. PMID: 12066082 http://resourcecenter.msn.com/access/plans/2monthsfree.asp Next message: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Previous message: Garry E. Siegel, M.D.: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Maybe in reply to: Dean Huffman: "MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Next in thread: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Luis Sanchez-Ramos, MD: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic" Reply: Myer Bornstein: "Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic"

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