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Re: ERT/HRT- personal prescribing trend From: Dr. Abdelhamid Attia (aattia@thewayout.net) Sun Oct 20 05:38:53 2002 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Joanne Bulley, MD: "Re: ERT/HRT- personal prescribing trend" Previous message: Garry E. Siegel, M.D.: "Re: Gyn: PCO" Maybe in reply to: Zach Newton: "ERT/HRT- personal prescribing trend" Next in thread: Dib Abdalla Chacur: "Re: ERT/HRT- personal prescribing trend" No! It is not the estrogen. A study done by Shairer et al., 2000 analyzing the follow-up data of 46,355 postmenopausal women found a 1% (0.01) yearly increase in the RR of developing a breast cancer in estrogen only users versus an 8% (0.08) yearly increase in RR in estrogen+progetin users. This means that after 5 years of use there would be a 5% and 40% increase in the RR of breast cancer in ERT versus HRT users (RR 1.05 & 1.4 respectively). So, it may be the progestin added or a combined effect that leads to the increased incidence of breast cancer. Shairer et al. Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk. JAMA 2000; 283:485-491 -- Abdelhamid Attia Dr. Abdelhamid Attia A. Prof. of Ob & Gyn Faculty of Medicine - Cairo Univ. http://www.geocities.com/thetropics/7210 > ----- Original Message ----- From: Joanne Bulley, MD To: Multiple recipients of list OB-GYN-L Sent: Saturday, October 19, 2002 4:39 AM Subject: Re: ERT/HRT- personal prescribing trend Also - those saying HRT was "bad for the breast" always said it was the estrogen - so ... gee ... the Premarin only arm is still going on - so the issue of cause versus stimulating one that was going to be ther anyway needs a thoughtful evaluation. Next message: Joanne Bulley, MD: "Re: ERT/HRT- personal prescribing trend" Previous message: Garry E. Siegel, M.D.: "Re: Gyn: PCO" Maybe in reply to: Zach Newton: "ERT/HRT- personal prescribing trend" Next in thread: Dib Abdalla Chacur: "Re: ERT/HRT- personal prescribing trend"

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