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Re: Determination of fetal RhD status by Free DNA From: Charlie Chambers (cchamber@gorge.net) Wed Oct 9 12:36:29 2002 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: art fougner, md: "OB: The 80 Million Dollar Child" Previous message: Charlie Chambers: "time article" Also suggest the Perinatal Genetics Division at the University of Utah, and speak with Ken Ward. If his DNA lab doesn't run the test, he'll certainly know who does near your office. On Tuesday, October 8, 2002, at 07:48 PM, jafar6 wrote: > I have a multiparous patient who is Rh sensitized (anti-D). With her > last > (2nd) pregnancy, her anti-D titer rose from 1/16 to 1/128 at about 24 > weeks. > Rh genotyping by amniocentesis showed the fetus to be Rh negative. > Although > middle cerebral artery Dopplers suggested that the fetus was not > anemic, the > rising anti-D titers led us to perform the amniocentesis. The baby was > fine. > > She delivered an unaffected Rh positive fetus in her first pregnancy > (with > a different father). An amniocentesis was also done during that > pregnancy > for delta OD 450, at about 36 weeks. > > This pregnancy is with the same father as the last pregnancy. He is Rh+ > (and > probably heterozygous for RhD, assuming paternity). > > This time, we would like to avoid amniocentesis, if possible. Articles > have > suggested that sampling maternal blood for free fetal DNA is sensitive > and > specific for the fetal RhD gene and therefore the fetal Rh phenotype. > > Has anyone here used this technique? Does anyone know of a clinical or > research lab that could do it? > > Thanks in advance, > > Gary Kleinman, M.D. > Pisces > ************************************************************************** **** Charlie Chambers -- Hood River, OR USA cchamber@alumni.rice.edu "All good things...come by grace, and grace comes by art, and art does not come easy." Norman Maclean ************************************************************************** ***** Next message: art fougner, md: "OB: The 80 Million Dollar Child" Previous message: Charlie Chambers: "time article"

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