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Re: Determination of fetal RhD status by Free DNA From: art fougner, md (evsono@pipeline.com) Wed Oct 9 11:23:17 2002 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Charlie Chambers: "time article" Previous message: Lynn D. Montgomery, M.D.: "Re: Determination of fetal RhD status by Free DNA" In reply to: jafar6: "Determination of fetal RhD status by Free DNA" why not contact Diana Bianchi, MD at NEMC? worth a shot. otherwise Ken Moise would prolly know. art At Tue, 08 Oct 2002, jafar6 wrote: > >I have a multiparous patient who is Rh sensitized (anti-D). With her last >(2nd) pregnancy, her anti-D titer rose from 1/16 to 1/128 at about 24 weeks. >Rh genotyping by amniocentesis showed the fetus to be Rh negative. Although >middle cerebral artery Dopplers suggested that the fetus was not anemic, the >rising anti-D titers led us to perform the amniocentesis. The baby was fine. > > She delivered an unaffected Rh positive fetus in her first pregnancy (with >a different father). An amniocentesis was also done during that pregnancy >for delta OD 450, at about 36 weeks. > >This pregnancy is with the same father as the last pregnancy. He is Rh+ (and >probably heterozygous for RhD, assuming paternity). > >This time, we would like to avoid amniocentesis, if possible. Articles have >suggested that sampling maternal blood for free fetal DNA is sensitive and >specific for the fetal RhD gene and therefore the fetal Rh phenotype. > >Has anyone here used this technique? Does anyone know of a clinical or >research lab that could do it? > >Thanks in advance, > >Gary Kleinman, M.D. >Pisces -- art fougner, md ich bin ein New Yorker Next message: Charlie Chambers: "time article" Previous message: Lynn D. Montgomery, M.D.: "Re: Determination of fetal RhD status by Free DNA" In reply to: jafar6: "Determination of fetal RhD status by Free DNA"

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