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Re: Thrombophylia and recurrent abortionsFrom: Mark Perloe (mperloe@ivf.com)Wed Jul 3 13:31:44 2002
>... I explained that inadequate progesterone was a possible cause of about 5% >of miscarriages, and that progesterone supplementation is a >controversial subject. I'm not aware of evidence to support that progesterone deficiency is in fact the cause. How can you separate progesterone level from granulosa cell abnormality, FSH deficiency, poor follicular blood flow, or abnormal oocytes. I think these latter are all associated with a low progesterone level, and giving progesterone will not fix any of those issues. Giving topical progesterone is worthless plain and simple. There are very large amounts of 5 alpha reductase in the skin which will metabolize up to 98% of any P administered topically. But they will feel good, since the 5 alpha reduced progesterone will bind to the Cl ion channel receptor, the same place valium binds.
-- Mark Perloe, M.D. http://grs.ivf.com 404-843-2229 5445 Meridian Mark Rd, Suite 270, Atlanta, GA 30342
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