Re: ortho-evra bc patch

From: art fougner, md (evsono@pipeline.com)
Mon Apr 22 18:26:30 2002


just a line of thought - not based on company data but prolly a dilutional effect relating dosing to body surface area - the greater the body surface area - the greater the dilution - eventually the efficacy is reduced below a critical level.

just my opinion - i could be wrong.

art

At Mon, 22 Apr 2002, JSBowpat@aol.com wrote: >
>The question regarding the reduced contraceptive efficacy and the patch was
>posed to the Ortho rep in our office not too long ago. He indicated that
>similar findings have been found with OCPs, but is still a highly effective
>method. At a recent conference, J.K. Williams out of USF (where they did
>phase 3 trials) related that a review of the data showed 15 failures with the
>patch out of a number I can't recall, but it was in the thousands. Most of
>those failures involved women over 200 lbs. He also related that for
>teenagers, this was a particularly effective form of birth control, having
>only to put it on once a week, and that in the trials, they never had any
>problem with the patch falling off, and that they tested in women doing
>regular aerobic exercise, where they sweat a lot.
>
>Judith E. Bowers DO
>Susan A. Paterson CNM
>Bay City MI

--
art fougner, md
ich bin ein New Yorker




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