GEN: as the pendulum swings

From: art fougner, md (evsono@pipeline.com)
Thu Apr 11 16:49:27 2002


this in today's Reuters Health News. this seems apropos in view of recent comments re: circumcision.

Circumcision reduces risk of penile HPV infection, cervical cancer in partners

Last Updated: 2002-04-10 17:00:44 EDT (Reuters Health)

NEW YORK (Reuters Health) - Circumcised men are less likely to carry genital human papillomavirus (HPV) infection, a multinational team of investigators reports in the New England Journal of Medicine for April 11.

A result of this reduced carriage rate is that a monogamous woman whose male sexual partner has have a history of high-risk sexual behavior is less likely to develop cervical cancer if the partner is circumcised and than if he is not.

In seven case-control studies conducted on three continents, men who were long-term partners of 610 monogamous women with cervical cancer and those of 533 matched control women were tested for penile HPV infection by PCR assay. Nearly 20% of the men were circumcised, ranging from 1.5% in Colombia to 91.0% in the Philippines.

Dr. Xavier Castellsagué, of the Hospitalet de Llobregat in Barcelona, Spain, and associates report that HPV DNA was detected in 19.6% of the uncircumcised men and in 5.5% of those who were circumcised.

"Male circumcision was associated with a moderate, but nonsignificant, decrease in the risk of cervical cancer in the men's female partners," the investigators report. However, there was a significant inverse association between circumcision and the partner's risk of cervical cancer when the man had a history of six or more sexual partners (p 0.03).

In an editorial, Dr. Hans-Olov Adami from the Karolinska Institutet in Stockholm and Dr. Dimitrios Trichopoulos from the Harvard School of Public Health in Boston estimate that, assuming 25% of men are already circumcised, "the general adoption of circumcision might lead to a further reduction in the incidence of cancer of the cervix of 23 to 43 percent."

In addition, the commentators point out, circumcision is associated with reduced risk of penile cancer and of HIV infection, lending the possibility of "considerable public health benefits" to increased rates of circumcision.

N Engl J Med 2002;346:1105-1112.

don't shoot me - am just the messenger.

art

--
art fougner, md
ich bin ein New Yorker




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