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Re: Protein creatinine ratioFrom: Braun, R. Daniel (rbraun@iupui.edu)Thu Mar 21 04:29:32 2002
There are studies on this going back at least 30 years. They all show similar findings, but no one ever gets convinced that it is worthwhile changing because it isn't quite as good as the GOLD STANDARD. Almost but not quite. When we used urinary estriols, the Estriol Creatinine ratio was evaluated. It wasn't as good as the 24 hr collection R. Daniel Braun, MD There are strange things done in the midnight sun By the men who moil for gold; The Arctic trails have their secret tales That would make your blood run cold; The Northern Lights have seen queer sights, But the queerest they ever did see Was that night on the marge of Lake Lebarge I cremated Sam McGee. Robert W Service -----Original Message----- From: Montgomery, Lynn MD [mailto:LMontgomery@COMMUNITYMED.ORG] Sent: Thursday, March 14, 2002 2:25 PM To: Multiple recipients of list OB-GYN-L Subject: Re: Protein creatinine ratio This is why I ask. Abstract from this years SMFM meeting: "Prospective prediction of 24 hour proteinuria by spot protein creatinine ratio. Binno, et.al. Objective: The degree of proteinuria is frequently assessed in obstetric patients with preeclampsia, diabetes and other medical complications. The gold standard has been a 24 hour collection of urine. Obviously collecting urine for 24 hours is cumbersome and may frequently result in erroneous results secondary to incomplete collections. In the non-obstetric population, the spot Protein Creatinine Ratio (PCR) is used to assess the degree of proteinuria. This study examined the prospective prediction of the 24 hour proteinuria using the spot PCR in obstetric patients. Study Design: One hundred-twenty antepartum patients with a variety of medical indications, were asked to obtain a 24 hour urine specimen at home, on the day prior to their clinic visit. At their clinic visit they were asked to obtain a single urine sample for the spot PCR. The 24 hour urine protein content was measured in the laboratory. The spot PCR was used to predict the 24 hour urine protein content and the correlation between the measured 24 hour urine protein and the predicted 24 hour urine protein is presented.
Results: Ninety five patients completed the urine collections
for data analysis. The Peason coefficient for the correlation
between the measured and the predicted 24 hour urine protein
was 0.903, with R-squared value of 0.815 and a P < .001. The
24 hour proteinuria < 300mg was accurately predicted in 63 out
of 68 patients, proteinuria between 300mg and 5 grams was
accurately predicted in 20 out of 23 patients and proteinuria
> 5 grams was accurately predicted in all remaining cases. Conclusion: These results confirm that the spot Protein Creatinine Ratio is a highly reliable assessment for the degree of proteinuria in the pregnant population. Using PCR will enhance patient care and will be cost saving as well." So if it can't be done, how did they do it? Lynn -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net]On Behalf Of Steve & Eryl Raymond Sent: Thursday, March 14, 2002 10:31 AM To: Multiple recipients of list OB-GYN-L Subject: Re: Protein creatinine ratio Can't be done. Total urinary excretion varies diurnally. stray "Montgomery, Lynn MD" wrote:
> Hey y'all,
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