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Re: antiphospholipid antibody syndrome Which labs to look at From: Mark Perloe (mperloe@ivf.com) Tue Mar 19 19:54:54 2002 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Ricardo Savaris: "Sibutramine in pregnancy" Previous message: DMECNM@aol.com: "Re: Dean Huffman" In reply to: C.Moi,M.D: "antiphospholipid antibody syndrome Which labs to look at or order?" If you order an entire panel of antiphospholipids, you are bound to see one or two positive values due to standards that are set at 95% confidence values. This means that in any given population you will have 5% false positive or negatives, or on average 1:20 tests will be positive in a normal individual. As such, significant antiphospholipid syndrome is best defined when clinical findings other than first trimester losses are present. Mutliple positive values in the moderate to high range should be considered. Low level IgM antibodies are not significant. Studies looking at other than cardiolipin lack good standardization and controlled studies. Antiphosphoserine may be associated with a larger body of evidence suggesting it plays a role than the others. But, these antibodies should be persistent and mod-high levels for multiple antibodies to indicate a significant risk. At 01:06 AM 3/19/2002 -0600, you wrote: >While working up a pt with habitual abortion I oredred antiphospholipid >antibody titre , what I got back was IGC & IGM & IGG for each of the >following: >Phosphoethanolamine,Phosphatidic cid,Phosphoresine..all these Normal >Phosphoglycerol.Phosphoinositol,Phosphatidylchol...all these were >elevated >Now which ones do I look at ? which have significance? >Or did I get the wrong tests? >Thanks for any help -- Mark Perloe, M.D. http://grs.ivf.com 404-843-2229 5445 Meridian Mark Rd, Suite 270, Atlanta, GA 30342 Live Chat Wednesday evenings 8:00-9:00 p.m. ET http://infertility.about.com/gi/chat/cs.htm Next message: Ricardo Savaris: "Sibutramine in pregnancy" Previous message: DMECNM@aol.com: "Re: Dean Huffman" In reply to: C.Moi,M.D: "antiphospholipid antibody syndrome Which labs to look at or order?"

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