Re: Protein creatinine ratio
From: Joanne Bulley, MD (islesannie@yahoo.com)
Sat Mar 16 06:37:42 2002
When I did Ob ... These patientes were often admitted at 3 PM - sent
over from the office - and we wanted an idea by the next morning. Even
though we knew it wasn't the "gold standard" - we would do a 12 hour
urine - and as soon as that was sent start a 24 hour urine. Then by the
time we were doing rounds at 7-8 AM we had the data of how much was
excreted in the 12 hours to make an initial decision of whether to start
inducing know or whether we could sit on the time bomb for a bit... It
semmed to pretty well correlate with the 24 hour one that we got the
next day. I suppose we coule have thought of publishing...
Joanne
At Sat, 16 Mar 2002, Braun, R. Daniel wrote:
>
> Actually according to a very well done study about 10 years ago, the dip
>does not correlate at all with the 24 hour total. In the study they had idps
>that were negatiove in women who had over 4 grams in their 24 hour sample
>and 4+ on dips in women who had 200 mg in the 24 hour sample. The protein is
>not excreted in a steady manner but in peaks and valleys.
>
>Dan
>
>-----Original Message-----
>From: Steve & Eryl RaymondTo: Multiple recipients of list OB-GYN-L
>Sent: 3/15/2002 4:57 PM
>Subject: Re: Protein creatinine ratio
>
>You're quite right, there is a correlation, and it probably is close
>enough for
>clinical use, but I was thinking you were asking if it could be possible
>to
>predict exactly - see your question at the bottom. On the other hand
>what does
>it tell you in an obstetric population that you can't tell from a simple
>dipstick?
>stray
>
>"Montgomery, Lynn MD" wrote:
>
>> This is why I ask. Abstract from this years SMFM meeting:
>>
>> "Prospective prediction of 24 hour proteinuria by spot protein
>> creatinine ratio. Binno, et.al.
>>
>> Results: Ninety five patients completed the urine
>collections
>> for data analysis. The Peason coefficient for the correlation
>> between the measured and the predicted 24 hour urine protein
>> was 0.903, with R-squared value of 0.815 and a P < .001. The
>> 24 hour proteinuria < 300mg was accurately predicted in 63 out
>> of 68 patients, proteinuria between 300mg and 5 grams was
>> accurately predicted in 20 out of 23 patients and proteinuria
>> > 5 grams was accurately predicted in all remaining cases.
>>
>> Conclusion: These results confirm that the spot Protein
>Creatinine
>> Ratio is a highly reliable assessment for the degree of
>proteinuria
>> in the pregnant population. Using PCR will enhance patient
>care
>> and will be cost saving as well."
>>
>> So if it can't be done, how did they do it?
>> Lynn
>>
>> > This may be a stupid question, but does anybody know how to convert
>a spot
>> > protein creatinine ratio into an equivalent total 24 hour protein
>amount?
>> > Lynn
>>
>> --
>>
>> Dr.S.H. Raymond
>> Head of Department of O & G
>> Empangeni Hospital
>> South Africa 3880
>> Phone: (+27) 35-7721111
>> Fax: (+27) 35-7922596
>
>--
>
>Dr.S.H. Raymond
>Head of Department of O & G
>Empangeni Hospital
>South Africa 3880
>Phone: (+27) 35-7721111
>Fax: (+27) 35-7922596
>
--
Joanne Bulley, MD
Keene, NH, USA
~*~ let there be peace on earth and let it begin with me ~*~
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