Re: Protein creatinine ratio
From: ainsron@msn.com
Thu Mar 14 21:13:06 2002
Spot urine protein/creatinine ratio: < 12 mg/mmol = normal; and > 300 nephrotic.
this is per an online reference I found. Never used it myself.
At Thu, 14 Mar 2002, Montgomery, Lynn MD wrote:
>
>This is why I ask. Abstract from this years SMFM meeting:
>
> "Prospective prediction of 24 hour proteinuria by spot protein
> creatinine ratio. Binno, et.al.
>
> Objective: The degree of proteinuria is frequently assessed
> in obstetric patients with preeclampsia, diabetes and other
> medical complications. The gold standard has been a 24 hour
> collection of urine. Obviously collecting urine for 24 hours
> is cumbersome and may frequently result in erroneous results
> secondary to incomplete collections. In the non-obstetric
> population, the spot Protein Creatinine Ratio (PCR) is used
> to assess the degree of proteinuria. This study examined the
> prospective prediction of the 24 hour proteinuria using the
> spot PCR in obstetric patients.
>
> Study Design: One hundred-twenty antepartum patients with a
> variety of medical indications, were asked to obtain a 24 hour
> urine specimen at home, on the day prior to their clinic visit.
> At their clinic visit they were asked to obtain a single urine
> sample for the spot PCR. The 24 hour urine protein content was
> measured in the laboratory. The spot PCR was used to predict
> the 24 hour urine protein content and the correlation between
> the measured 24 hour urine protein and the predicted 24 hour
> urine protein is presented.
>
> Results: Ninety five patients completed the urine collections
> for data analysis. The Peason coefficient for the correlation
> between the measured and the predicted 24 hour urine protein
> was 0.903, with R-squared value of 0.815 and a P < .001. The
> 24 hour proteinuria < 300mg was accurately predicted in 63 out
> of 68 patients, proteinuria between 300mg and 5 grams was
> accurately predicted in 20 out of 23 patients and proteinuria
> > 5 grams was accurately predicted in all remaining cases.
>
> Conclusion: These results confirm that the spot Protein Creatinine
> Ratio is a highly reliable assessment for the degree of proteinuria
> in the pregnant population. Using PCR will enhance patient care
> and will be cost saving as well."
>
>So if it can't be done, how did they do it?
>Lynn
>
>-----Original Message-----
>From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net]On Behalf Of Steve &
>Eryl Raymond
>Sent: Thursday, March 14, 2002 10:31 AM
>To: Multiple recipients of list OB-GYN-L
>Subject: Re: Protein creatinine ratio
>
>Can't be done. Total urinary excretion varies diurnally.
>stray
>
>"Montgomery, Lynn MD" wrote:
>
>> Hey y'all,
>> This may be a stupid question, but does anybody know how to convert a spot
>> protein creatinine ratio into an equivalent total 24 hour protein amount?
>> Lynn
>>
>> Lynn D. Montgomery, M.D.
>> Director, Maternal-Fetal Medicine
>> Rocky Mountain Perinatal Center
>> 2825 Fort Missoula Rd, Suite 130
>> Missoula, Montana, 59804
>> 406-327-4094
>> fax: 406-327-4154
>> e-mail: lmontgomery@communitymed.org
>> website: http://www.communitymed.org/rmpc/
>
>--
>
>Dr.S.H. Raymond
>Head of Department of O & G
>Empangeni Hospital
>South Africa 3880
>Phone: (+27) 35-7721111
>Fax: (+27) 35-7922596
>
--
Ronald E. Ainsworth, MD
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