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Re: DroperidolFrom: ainsron@msn.comWed Jan 30 21:42:24 2002
They need to look at the indications. It is not recommended for routine postop N&V. It should be reserved for the "tough" cases: INDICATIONS AND USAGE: 1. Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. Efficacy of the 32-mg single dose beyond 24 hours in these patients has not been established. 2. Prevention of postoperative nausea and/or vomiting. As with other antiemetics, routine prophylaxis is not recommended for patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided postoperatively, ZOFRAN Injection is recommended even where the incidence of postoperative nausea and/or vomiting is low. For patients who do not receive prophylactic ZOFRAN Injection and experience nausea and/or vomiting postoperatively, ZOFRAN Injection may be given to prevent further episodes >Zofran too expensive? Tell that to the surgeons in my town. It's on >everybody's routine standing orders. The ortho who fixed my feet >ordered it and I tossed cookies all night til the nurse finally called >him at 5AM to ask for a compazine order. The ENT who took out my kid's >tonsils ordered it even though I told him it didn't work for me at all. >My kid tossed cookies all day in spite of three doses of Zofran and the >ENT refused to order Compazine so I took her home still vomiting and got >some at the pharmacy. Hadn't heard there was an IV Compazine shortage. >Too bad. It's still my favorite. > >-- > Anna Meenan, MD > >At Wed, 30 Jan 2002, ainsron@sbcglobal.net wrote: >> >>Our hospital pharmacist recently pointed out to us that the FDA had >>added restrictions to the use of Droperidol because of deaths due to >>prolonged QT interval. Use is restricted to having an EKG before using, >>telemetery for 2-3 hours after each dose. He feels that it should only >>be a 3rd or 4th line agent now. Have any others been getting the same >>advice? I have to admit, it has been my favorite agent for postop nausea >>for a number of years and I hate to change, but will probably go to >>phenergan or reglan now. Vistaril can't be given IV, Zofran is too >>expensive for routine use, Compazine is basically not available IV due >>to a national shortage. >>See <http://www.fda.gov/medwatch/safety/2001/inapsine.htm> >> >>-- >>Ronald E. Ainsworth, MD >>
-- Ronald E. Ainsworth, MD
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