Re: Cigdem Arkuran's Reference

From: Luis Sanchez-Ramos, MD (luis.sanchez@jax.ufl.edu)
Tue Jul 31 12:14:43 2001


Bob;

That is a good point. There are a couple of studies (I can't seem to remember the exact references at this moment) assessing protein/creatinine ratios in spot urines. In addition, 6-hr and 12-hr urine collections have been suggested (when time is of the essence).

LSR

At Tue, 31 Jul 2001, Robert J Woolley wrote: >
>> With regard to the absence of proteinuria, I have no argument. As I
>> stated previously, even in eclampsia 7-10% have no proteinuria. However,
>> we must remember that the great majority of these patients had
>> proteinuria assessed by simple dipstick methods. 24-hour urine
>> collections were not performed. There are a couple of publications
>> which indicate that when compared to a 24-hour urine collection, the
>> assessment of proteinuria by disptick is far less reliable.
>
>Thanks for the comments.
>
>When one can't reasonably get a 24-hr urine because of time constraints or
>whatever, a better substitute than just a dipstick would be the ratio of
>urine protein (quantitative) to urine creatinine in a single
>specimen. This ratio has a high correlation with 24-hr urine protein. In
>fact, by happy coincidence, one doesn't even have to do any math; the
>conversion is 1:1. That is, if the spot protein/creat ratio is 3, the
>24-hr protein can be estimated at 3g.
>
>Caveat: although this is true in general internal medicine patients, I do
>not know that a similar correspondence has been established for women in
>late pregnancy. However, I still think it will give a better assessment
>that a dipstick.





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