Re: Degenerated fibriod and pregnancy

From: Efrain Ramirez (eramirez@icepr.com)
Wed May 30 07:44:44 2001


Do you have the reference for that? I'll love to have it - Sulindac is Clinoril - PDR's words are:

"Use in Pregnancy

CLINORIL is not recommended for use in pregnant women, since safety for use has not been established. The known effects of drugs of this class on the human fetus during the third trimester of pregnancy include: constriction of the ductus arteriosus prenatally, tricuspid incompetence, and pulmonary hypertension; non-closure of the ductus arteriosus postnatally which may be resistant to medical management; myocardial degenerative changes, platelet dysfunction with resultant bleeding, intracranial bleeding, renal dysfunction or failure, renal injury/dysgenesis which may result in prolonged or permanent renal failure, oligohydramnios, gastrointestinal bleeding or perforation, and increased risk of necrotizing enterocolitis."

It is not listed in http://www.perinatology.com/exposures/druglist.htm

Efrain

At Wed, 30 May 2001, Vik wrote: >
>If you want to stay away from narcotics, what works really well is also
>sulindac (i can't remember trade name) used it quite a bit in high risk
>in Detroit with MFM, worked very well, it is an nsaid but minimally
>crosses the placenta if at all
>
>At Tue, 29 May 2001, Joanne Bulley wrote:
>>
>>Dear (double) Dr. Rommel -
>>
>>Please look at the poster's name/location - English is not likely the
>>poster's primary language - and even those of us who spell very well hit
>>the wrong keys - frequently!
>>
>>I do agree that a fibroid needing medical attention is giving symptoms -
>>not merely present. And it usually responds to narcotics.
>>
>>Joanne
>>
>>At Mon, 28 May 2001, Betty Rommel, MD, PhD wrote:
>>>
>>>Poor speelling really gets my goat, but a large degenerating myoma
>>>usually causes pain and responds well to IM demerol administered PRN.
>>>
>>>--
>>>Betty Rommel, MD, PhD
>>>
>>--
>>Joanne Bulley, MD, FACOG
>>Keene, NH, USA
>>
>--
>Vik MD, NY
>

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