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Re: DHEA-S refs./PCOS defn. From: Rafael Haciski MD (haciski@earthlink.net) Tue Apr 24 00:00:59 2001 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Rafael Haciski MD: "Re: Resistant Trich?" Previous message: Joanne Bulley: "NY Times: Abortion in India Is Tipping Scales Sharply Against girls" In reply to: Jeffrey W. Clemens: "Re: DHEA-S refs./PCOS defn." To further confuse you: ...not all patients respond to Metformin; ...some patients who respond to Metformin initially, lapse back to their "evil ways" again after several months of treatment; You are most probably correct in assuming that it is a polygenic disorder, making a neat and clean theory unlikely. -- Rafael Haciski, MD FACOG Gynecology & Infertility Assoc. Baltimore MD http://www.ivf-md.com > From: "Jeffrey W. Clemens" <clemens@duq.edu> > Reply-To: ob-gyn-l@obgyn.net > Date: Mon, 23 Apr 2001 08:12:41 -0500 > To: Multiple recipients of list OB-GYN-L <ob-gyn-l@mail.medispecialty.com> > Subject: Re: DHEA-S refs./PCOS defn. > > Betsy, > > Thanks for the article. I believe the flow diagram SUGGESTS how insulin > could alter steroid biosynthesis. My very quick read of this and the > literature is that there are a lot of proposed mechanisms, but the molecular > evidence for any one of them is not there yet. Of course, confounding all > of these studies is the distinct possibility that this is a polygenic > disorder and doing the "traditional" genetics approach is not going to find > the multiple targets. Insulin certainly does have effects on steroidogenic > enzyme expression in vitro and metformin is effective, but my question still > remains unanswered. > >> At 8:52 AM 4/20/01, Jeffrey W. Clemens wrote: >>> >>> Poll part two- So metformin seems to work. Any real evidence of what it >>> does? At the level of the granulosa cell and/or thecal cell, what is it >>> doing? What gene's expression pattern/activity is being modified when you >>> get increased insulin/IGF signaling? >> >> you might want to look at the following article >> >> http://www.womenshealthpc.com/1_00/pdf/55PCOS.pdf >> >> There is a quite nice discussion/flow diagram which explains how increased >> insulin causes alterations in steroid biosynthesis. >> >> Betsy Hyde CNM >> Branford, CT >> > > -- > Jeffrey W. Clemens, Ph.D. > Assistant Professor, Biological Sciences > Duquesne University > Pittsburgh, PA 15282 > 412-396-4597 > fax-5907 > http://www.home.cc.duq.edu/~clemens/ > Next message: Rafael Haciski MD: "Re: Resistant Trich?" Previous message: Joanne Bulley: "NY Times: Abortion in India Is Tipping Scales Sharply Against girls" In reply to: Jeffrey W. Clemens: "Re: DHEA-S refs./PCOS defn."

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