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Re: DHEA-S refs./PCOS defn.From: Jeffrey W. Clemens (clemens@duq.edu)Mon Apr 23 08:11:52 2001
Betsy, Thanks for the article. I believe the flow diagram SUGGESTS how insulin could alter steroid biosynthesis. My very quick read of this and the literature is that there are a lot of proposed mechanisms, but the molecular evidence for any one of them is not there yet. Of course, confounding all of these studies is the distinct possibility that this is a polygenic disorder and doing the "traditional" genetics approach is not going to find the multiple targets. Insulin certainly does have effects on steroidogenic enzyme expression in vitro and metformin is effective, but my question still remains unanswered.
> At 8:52 AM 4/20/01, Jeffrey W. Clemens wrote:
-- Jeffrey W. Clemens, Ph.D. Assistant Professor, Biological Sciences Duquesne University Pittsburgh, PA 15282 412-396-4597 fax-5907 http://www.home.cc.duq.edu/~clemens/
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