Re: Fabre's Disease and CML

From: Griffiths Malcolm (Malcolm.Griffiths@ldh-tr.anglox.nhs.uk)
Fri Feb 23 02:15:42 2001


I know nothing of this condition, but my understanding is that ACE inhibitors need to be avoided in pregnancy as they are associated harmful effects on fetal kidneys.

In my hypertensive patients I always either stop ACE inhibitors or switch to another agent in the first trimester.

-----Original Message----- From: William Von Almen Ii [mailto:wfvaii@pol.net] Sent: 22 February 2001 18:31 To: Multiple recipients of list OB-GYN-L Subject: Fabre's Disease and CML

Oh exalted list

I have had 2 patients recently with problems I need help with. #1 Not pregnant, has Fabre's disease and is on diovan (ace inhib). This is an x-linked disease, mom has mild form, brother has kidney transplant. She is on diovan to correct proteinuria, not hypertension, she also has some joint crises and eye findings. Questions: Does she need meds if pregnant? High Risk for pre-eclampsia? Anything else?

#2 Husband has CML, very low grade at present. Mom wants to know inheritance and if it would be wise to bank cord blood, primarily for child, if at risk for disease.

Any help appreciated PS Happy Mardi Gras to all, I am on my way to Breckenridge!

William F. von Almen, II, MD, FACOG Private Practice New Orleans, La.

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