Re: LATIVE RISK

From: art fougner, md (evsono@pipeline.com)
Tue Feb 20 21:38:54 2001


would defer to Drs. Bombard and Roberts for the math but i'd suggest looking at this a different way. in Beryl Benacerraf's lab, they use a scoring system for their "genetic sonogram." age 40 or over achieves a score sufficient to warrant amnio without any sonar findings.

art

At Tue, 20 Feb 2001, Richard Chudacoff, MD wrote: >
>I have a friend (believe it or not) who is a 41 year old G3 P2 with a
>greater than 15 year history of IDDM. I don't believe she has any
>renal, eye, cardiac, or other end-organ problems, and she did mangae to
>get pregnant unintentially, while her Hbg A1C what slightly elevated.
>Currently she is at 12 weeks EGA and called me for advice.
>
>She has been offered a CVS for tomorrow (the last day her perinatologist
>would do it) and asked me my thoughts. While talking with her, we
>discussed the nuchal translucency test, and I came to ponder this
>question: What would be the chance of having an abnormal fetus with a
>normal 11-12 week nuchal translucency study, normal 15 week maternal
>serum alphafetoprotein and a normal 18 week level ll ultrasound? Would
>the false negative rate (i.e. the chance of having an abnormal fetus
>with normal testing in all three areas) approach that of an
>amniocentesis at 15 or 16 weeks? Would the rate of diagnosing an
>abnormal fetus using the combination of these three non-or-minimally
>invasive tests approach than of the invasive amniocentesis? True, the
>results of the amnio would be received sooner than waiting for the 18
>week ultrasound, but the risk of loss would be greater, too.
>
>Anyone out there with a mathamatical background that can answer this?
>
>Thanks
>
>Rick
>
>--
>Richard Chudacoff, MD
>Chudacoff Obstetrics & Gynecology, PLLC
>Sugar Land, TX
>

--
art fougner, md

A series of 1000 cases begins with but a single anecdote.





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