Re: Hypophosphatasia and pregnancy
From: art fougner, md (evsono@pipeline.com)
Wed Jan 10 09:11:30 2001
looks like a job for TJ & ATB. any thoughts guys?
art
At Tue, 09 Jan 2001, Kathi Wilson wrote:
>
>I have a question for you knowledgeable OB's and physiologist types. We
>have a nursing student w/ us right now (for a placement, not as a
>patient) who is pregnant and who has hypophosphatasia. She has a milder
>form, although her brother apparently had his femurs pinned at a fairly
>young age. I've done a medline search which hasn't been helpful to any
>degree, but we were idly wondering about her condition today, and my
>partner said "why dontcha ask the ob-gyn list?".
>
>Questions are these: Does pregnancy actually have a positive benefit in
>this instance because of the placental production of alk phos? The one
>paper that I managed to dig up the abstract for on medline, suggested
>that in the third trimester the hypophospatemia does correct, but would
>that be of any long-term benefit with respect to bone density? And what
>effect would breastfeeding have on this condition? It's certainly
>documented that breastfeeding itself can result in decreases in bone
>mineral (which rebounds upon weaning and apparently the rebound is
>higher, the longer the period of lactation, but I'm unsure as to the
>physiologic mechanism for this rebound, and whether it would occur in
>someone w/ hypophosphatasia).
>
>Any thoughts, idle or otherwise, would be interesting.
>
>--
>Kathi Wilson, RM
>Ilderton, Ontario, Canada
>mailto:wilsonk@gtn.on.ca
>**********************
>Thames Valley Midwives
>**********************
>346 Platts Lane,
>London, Ontario, Canada
>
>http://tvm.on.ca
>mailto:info@tvm.on.ca
>
--
art fougner, md
A series of 1000 cases begins with but a single anecdote.
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