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Hypophosphatasia and pregnancy From: Kathi Wilson (wilsonk@gtn.on.ca) Tue Jan 9 20:04:27 2001 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Jaynie St. Pierre, RN,BSN,FNP Graduate Student: "Re: Thesis re: Pain Perception in Fibromyalgia pts. with hx of Endo" Previous message: Kathi Wilson: "Re: fever after epidural" Next in thread: art fougner, md: "Re: Hypophosphatasia and pregnancy" Reply: art fougner, md: "Re: Hypophosphatasia and pregnancy" I have a question for you knowledgeable OB's and physiologist types. We have a nursing student w/ us right now (for a placement, not as a patient) who is pregnant and who has hypophosphatasia. She has a milder form, although her brother apparently had his femurs pinned at a fairly young age. I've done a medline search which hasn't been helpful to any degree, but we were idly wondering about her condition today, and my partner said "why dontcha ask the ob-gyn list?". Questions are these: Does pregnancy actually have a positive benefit in this instance because of the placental production of alk phos? The one paper that I managed to dig up the abstract for on medline, suggested that in the third trimester the hypophospatemia does correct, but would that be of any long-term benefit with respect to bone density? And what effect would breastfeeding have on this condition? It's certainly documented that breastfeeding itself can result in decreases in bone mineral (which rebounds upon weaning and apparently the rebound is higher, the longer the period of lactation, but I'm unsure as to the physiologic mechanism for this rebound, and whether it would occur in someone w/ hypophosphatasia). Any thoughts, idle or otherwise, would be interesting. -- Kathi Wilson, RM Ilderton, Ontario, Canada mailto:wilsonk@gtn.on.ca ********************** Thames Valley Midwives 346 Platts Lane, London, Ontario, Canada http://tvm.on.ca mailto:info@tvm.on.ca Next message: Jaynie St. Pierre, RN,BSN,FNP Graduate Student: "Re: Thesis re: Pain Perception in Fibromyalgia pts. with hx of Endo" Previous message: Kathi Wilson: "Re: fever after epidural" Next in thread: art fougner, md: "Re: Hypophosphatasia and pregnancy" Reply: art fougner, md: "Re: Hypophosphatasia and pregnancy"

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