Re: Labor-Inducing Drug Associated With 8 Deaths

From: Luis Sanchez-Ramos, MD (luis.sanchez@jax.ufl.edu)
Fri Dec 22 06:12:48 2000


Malcolm:

Do you know whether these were maternal or perinatal deaths? Were they a combination of both? Did some of the mothers die of amniotic fluid embolism? Were some peroinatal deaths related to causes other than the drug used for induction? Do you know for a fact that the numbers are correct? This was not written in the American Journal of Obstetrics and Gynecology or in Obstetrics and Gynecology! More important: do you know what the denominator is? How do you know that the minority of obstetricians in the USA use misoprostol for cervical ripening and labor induction? Do you utilize off-label drugs in the United Kingdom? I KNOW that you lack answers to the majority of the above questions. Since you don't know much about the veracity of the article perhaps your comments should have been more positive...even though you don't use misoprostol...yet!

LSR

At Thu, 21 Dec 2000, Griffiths Malcolm wrote: >
>I would be very concerned if even in a large population such as the USA that
>there had been eight deaths associated with induction of labour let alone
>form induction of labour by an off-label product only being used by a
>minority of ob/gyns. Death seems to me to e a definite end-point and one
>that one can't argue with.
>
>This information would cause me concerns and I would not be so dismissive.
>
>-----Original Message-----
>From: marcop@agoron.com [mailto:marcop@agoron.com]
>Sent: 21 December 2000 13:27
>To: Multiple recipients of list OB-GYN-L
>Subject: Re: Labor-Inducing Drug Associated With 8 Deaths
>
>>Mother Jones contributing writer David Goodman reports that deaths
>resulting
>>from the "off-label" use of Cytotec have become the subject of several
>>lawsuits, including two in Oregon and others in Texas and Connecticut.
>After
>>being named as a defendant in a Portland, Oregon, suit, the drug's
>>manufacturer, G.D. Searle Corporation, sent a letter to 200,000 health care
>>providers warning them that "Cytotec administration by any route is
>>contraindicated in women who are pregnant because it can cause abortion."
>>(The drug is, in fact, used in combination with RU-486, for this specific
>>purpose.) The company also noted that off-label use of the drug has
>resulted
>>in reports of uterine rupture, hysterectomy, and the death of mothers and
>>infants....
>
>What do you expect from radical Leftists? You must keep in mind that the
>government, big corporations and organized medicine are in collusion to
>harm everyone. I'm surprised they haven't linked Cytotec to the Kennedy
>assassination and Area 51.
>
>--
>M.A. Pelosi, III, MD
>





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