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Re: OB: Kidd JK(A) sensitization From: ainsron@msn.com Wed Nov 8 11:59:38 2000 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: art fougner, md: "Re: OB: Placental Mosaism" Previous message: Larry Glazerman: "Re: OB: Placental Mosaism" In reply to: Garry Siegel: "OB: Kidd JK(A) sensitization" Obstetrics & Gynecology, February 1997, Volume 89, Number 2 Pages 272 - 275 Female Alloimmunization With Antibodies Known to Cause Hemolytic Disease Ossie Geifman-Holtzman, MD,a Martha Wojtowycz, PhD,a Eleni Kosmas,a and Raul Artal, MDa Objective: To determine the current frequency of red blood cell antigen alloimmunizations that are capable of causing hemolytic disease and would be suitable for prenatal DNA studies. Methods: We reviewed blood-bank records at a single large tertiary center to identify patients with a positive antibody screen between January 1993 and June 1995. Data were analyzed based on age, gender, and specific blood-group alloimmunizations. The incidence of antibodies as published in the literature was reviewed and compared with our data. Results: We identified 452 women who had a positive antibody screen. The frequencies of specific alloimmunization relevant to the development of fetal hemolytic disease were: anti-D, 18.4%; anti-E, 14%; anti-c, 5.8%; anti-C, 4.7%; Kell group, 22%; anti-MNS, 4.7%; anti-Fya (Duffy), 5.4%; and anti-Jka, 1.5%. Compared with other populations, in our group the frequency of antibodies to RhD decreased and Kell alloimmunization increased between 1967 and 1996. Conclusions: Despite the use of rhesus immune globulin, anti-D is still a common antibody identified in women presenting to a tertiary care center. The frequency of the Kell-group alloimmunization is higher among the central New York female population than in other populations. Rhesus and Kell antigen status can be determined by DNA studies. Research in prenatal determination of fetal antigen status should continue, as alloimmunization to these antigens is common. This article also had a table listing the frequency of the different antibodies from five other studies. >I'm looking online, but does anyone have any thoughts/reference on the >frequency of Kidd antigen positivity/negativity in the population (this >is US, caucasian)? > >Garry > >(BTW, the couple is young, together since age 16, very rural, and while >nice/polite/churchgoer types, isn't among the leaders in RAM or hard >drive space up top. That said, as I explained this, drew pictures, used >analogies such an bee stings (antibodies and antigens), she seemed to >get it, but kind of looked up and asked me, "Now why did you ask me if I >was the father of the other pregnancies?" It was all I could do to keep >a smirk off of my face.) > >-- >Garry E. Siegel, M.D., F.A.C.O.G. >Roswell, GA >Private Practice > -- Ronald E. Ainsworth, MD Next message: art fougner, md: "Re: OB: Placental Mosaism" Previous message: Larry Glazerman: "Re: OB: Placental Mosaism" In reply to: Garry Siegel: "OB: Kidd JK(A) sensitization"

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