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Re: OB: AFP Triscreens in subsequent pregnancies From: art fougner, md (evsono@pipeline.com) Wed Nov 8 10:00:07 2000 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: art fougner, md: "Re: OB: Kidd JK(A) sensitization" Previous message: Kirsten Duckitt: "Re: OB: AFP Triscreens in subsequent pregnancies" In reply to: Kirsten Duckitt: "Re: OB: AFP Triscreens in subsequent pregnancies" Next in thread: ATB28@aol.com: "Re: OB: AFP Triscreens in subsequent pregnancies" an observation - most abnormal down's screens are not an abnormally low AFP but an abnormally high HCG. would love someone to stratify the risks according to which component correlates best with a true positive. art At Wed, 8 Nov 2000, Kirsten Duckitt wrote: > >I had always understood that the AFP measured in the mothers serum is a reflection of the AFP produced by the fetus which is produced in a different amount by a fetus with trisomy 21 (for whatever reason). Therefore, it must be different with each pregnancy. Age is an independent variable factored into the equation along with the AFP level so yes that will skew the reuslt as she gets older. > >-- >Kirsten Duckitt >Clinical Lecturer >Nuffield Department of Obstetrics and Gynaecology >Level 3, Women's Centre >John Radcliffe Hospital >Headington >Oxford >OX3 9DU > >01865 741166 bleep 1028 > >>>> garrys@mindspring.com 11/08/00 01:58am >>> >I'm doing a medline, but curious. Does anyone have any thoughts/data >references regarding a question I was asked today. > >The patient said that since her AFP triscreens had been normal with her >two prior pregnancies, does that make her chances of it being normal >this time better/worse/no different? > >My gut says that each is an independent event, and that as she ages, the >likelihood of an abnormal result with respect to Down sceening will be >increased. > >Garry > >-- >Garry E. Siegel, M.D., F.A.C.O.G. >Roswell, GA >Private Practice > -- art fougner, md A series of 1000 cases begins with but a single anecdote. Next message: art fougner, md: "Re: OB: Kidd JK(A) sensitization" Previous message: Kirsten Duckitt: "Re: OB: AFP Triscreens in subsequent pregnancies" In reply to: Kirsten Duckitt: "Re: OB: AFP Triscreens in subsequent pregnancies" Next in thread: ATB28@aol.com: "Re: OB: AFP Triscreens in subsequent pregnancies"

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