Re: OB: Placental Mosaism

From: art fougner, md (evsono@pipeline.com)
Wed Nov 8 07:25:12 2000


the evidence for higher cvs loss rate is???

art

At Tue, 7 Nov 2000, Garry Siegel wrote: >
>Well, the next question tonight, and I'm doing a medline/looking at
>texts tomorrow in the office.
>
>A 40 YO gravida with a prior trisomy-13 found at 15 week amnio
>(terminated) now is 11 weeks, and contemplating CVS versus amnio. In
>her internet research, the issue of mosaicism found an CVS came up. The
>gist of her question was, "Why do a CVS that may lead me to need an
>amnio, rather than just do an amnio? The CVS has a higher loss rate."
>
>So, I wonder and am researching:
>
>How often is mosaicism found at CVS? Do we get percentages, i.e. 90% of
>the cells are 46 XX (or XY), and 10% are whatever?
>
>At what point do you need more info, i.e. an amnio or PUBS??
>
>How often is mosaicism found in term plancentas, or what percentage of
>cells (if any) are mosaic? What is the significance?
>
>Thanks
>
>Garry
>
>--
>Garry E. Siegel, M.D., F.A.C.O.G.
>Roswell, GA
>Private Practice
>

--
art fougner, md

A series of 1000 cases begins with but a single anecdote.





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