Factor V Leiden and OCs

From: ainsron@msn.com
Thu Nov 2 20:27:57 2000


I have a 47 yo non-smoking female with perimenopausal DUB, secretory endometrium on biopsy. I'm considering placing her on BCPs to regulate her cycles for a few months/years, but it turns out that she is positive for Factor V Leiden mutation. No personal history of thrombophlebitis. On reviewing information on the pill and thrombophlebitis, I'm uncertain whether or not this is an absolute contraindication to the pill. Speroff says that "studies of the blood coagulation system have concluded that both monophasic and multiphasic low dose OCs have no significant clinical impact on the coagulation system." Then in the next paragraph he says, "The minimal risk of thrombosis associated with OC use does not justify the cost of routine screening for deficiencies in the coagulation system. If a patient develops a thrombotic complication while taking OCs, an evaluation to search for an underlying abnormality in the coag system is warranted." Any opinions on whether or not OCs should be offered (short term or long term) to patients like this would be appreciated. Or if you know any other references that more directly address this issue, let me know.

--
Ronald E. Ainsworth, MD




use when must restrict search to only the ob-gyn-l forum...
Enter search keywords:
Returns per screen: Require all keywords:

Return to  OB-GYN-L Mail a New Message to the Forum: ob-gyn-l@obgyn.net
Forum Administrator: geffrey.klein@obgyn.net
Report Technical Problems: webmaster@obgyn.net
Last Updated: Mon Nov 2 04:46:22 2009

The American Medical Association is no longer designating CME hours for AMA Category II CME credit. However, physicians themselves may self designate learning activities as Category II CME credit hours if they feel it is of sufficient educational merit and meets the formal definitions of continuing medical education. OBGYN.net believes these interaction in this forum meets these criteria. For further information see the AMA web site.