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Factor V Leiden and OCsFrom: ainsron@msn.comThu Nov 2 20:27:57 2000
I have a 47 yo non-smoking female with perimenopausal DUB, secretory endometrium on biopsy. I'm considering placing her on BCPs to regulate her cycles for a few months/years, but it turns out that she is positive for Factor V Leiden mutation. No personal history of thrombophlebitis. On reviewing information on the pill and thrombophlebitis, I'm uncertain whether or not this is an absolute contraindication to the pill. Speroff says that "studies of the blood coagulation system have concluded that both monophasic and multiphasic low dose OCs have no significant clinical impact on the coagulation system." Then in the next paragraph he says, "The minimal risk of thrombosis associated with OC use does not justify the cost of routine screening for deficiencies in the coagulation system. If a patient develops a thrombotic complication while taking OCs, an evaluation to search for an underlying abnormality in the coag system is warranted." Any opinions on whether or not OCs should be offered (short term or long term) to patients like this would be appreciated. Or if you know any other references that more directly address this issue, let me know.
-- Ronald E. Ainsworth, MD
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