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OB: AMA just got younger From: art fougner, md (evsono@pipeline.com) Mon Oct 30 10:56:50 2000 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: art fougner, md: "OB: ACOG - get going on that cytotec bulletin already!" Previous message: Ealgail@aol.com: "Re: Perinatal morbity: was: List" in the November Green Journal - this report on congenital malformations - Maternal Age and Malformations in Singleton Births Lisa M. Hollier, MD, MPH,a Kenneth J. Leveno, MD,a Mary Ann Kelly, RN,a Donald D. McIntire, PhD,a and F. Gary Cunningham, MDa -------------------------------------------------------------------------------- Objective: To examine the effect of maternal age on incidence of -------------------------------------------------------------------------------- nonchromosomal fetal malformations. -- -------------------------------------------------------------------------------- Methods: Malformations detected at birth or in the newborn nursery were catalogued prospectively for 102,728 pregnancies, including abortions, stillbirths, and live births, from January 1, 1988 to December 31, 1994. Maternal age was divided into seven epochs. Relative risks (RRs) were used to compare demographic variables and specific malformations. The Mantel-Haenszel 2 statistic was used to compare age-specific anomalies. Multiple logistic regression analysis was used to adjust for parity. Results: Abnormal karyotypes were significantly more frequent in older women. After excluding infants with chromosomal abnormalities, the incidence of structurally malformed infants also was increased significantly and progressively in women 25 years of age or older. The additional age-related risk of nonchromosomal malformations was approximately 1% in women 35 years of age or older. The odds ratio for cardiac defects was 3.95 in infants of women 40 years of age or older (95% CI 1.70, 9.17) compared with women aged 20-24 years. The risks of clubfoot and diaphragmatic hernia also increased as maternal age increased. Conclusion: Advanced maternal age beyond 25 years was associated with significantly increased risk of fetuses having congenital malformations not caused by aneuploidy. aDepartment of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA (Obstet Gynecol 2000:96:701-706. © 2000 by The American College of Obstetricians and Gynecologists maybe those teens know something we don't? art -- art fougner, md A series of 1000 cases begins with but a single anecdote. Next message: art fougner, md: "OB: ACOG - get going on that cytotec bulletin already!" Previous message: Ealgail@aol.com: "Re: Perinatal morbity: was: List"

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