GYN: Continuous Combined Hormonal Therapy

From: Garry Siegel (garrys@mindspring.com)
Sun Oct 29 09:14:20 2000


How do you decide on which product/regimen to use for those menopausal patients in whom you prescribe long term, continuous comibined therapy? Until recently, the only available product in one pill/patch was Prempro. Here are the ones that I know about.

Prempro 2.5 (congugated estrogens 0.625 and MPA 2.5 mg)

Prepro 5 (congutated estrogens 0.625 and MPA 5 mg)

CombiPatch 50/140 (Estradiol 0.05 and Northinedrone Acetate [NETA]0.14)

CombiPatch 50/250 (Estradiol 0.05 and NETA 0.25)

FemHRT (Ethinyl Estradiol 0.05 and NETA 1 mg)

Activella (17 beta Estradiol 1 mg and NETA 0.5 mg)

Ortho Prefest (17ß-estradiol 1 mg/norgestimate 0.09 mg dosed on an intermittent basis—3 days off and 3 days on—in a continuously repeated pattern throughout therapy)

Other--for example, I have used estrogen equivalent to 0.625 Premarin and Prometrium 100 mg/day.

Anyway, I don't have an compelling reason to use one versus the other, and just wondered how others decided.

Garry

--
Garry E. Siegel, M.D., F.A.C.O.G.
Roswell, GA
Private Practice




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