Re: Another Interesting VBAC

From: Dean Huffman (jth@springnet1.com)
Sun Jul 16 09:36:48 2000


The issue of labeling of terbutaline apparently has been quite an issue for quite some time. A few years ago (I will try to find it) there was an interesting article by Hugh Barber on the issue. It seems that the drug companies have been fighting tooth and nail to put that wording in and have it stay there. I do not know how big a market IV terbutaline is for tocylysis, but it was certainly a big enough market for a company to make Yutopar. In any event, with the labeling as such, the drug companies can sell terbutaline for tocolysis as much as they want, and take the profits, but if anything ever goes wrong, they can point to the package insert and tell the judge or jury that, "...it was that damn doctor that gave the terbutaline and he did not even look at the package insert. IT IS THE DOCTOR'S FAULT AND WE ARE COMPLETELY INNOCENT."

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Dean Huffman

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Re: Another Interesting VBAC

From: Paul Prior MD (pprior@earthlink.net) Sun, 09 Jul 2000 12:58:19 -0400

On Sun, 9 Jul 2000 01:07:13 -0500, eramirez@icepr.com (Efrain Ramirez) wrote:

>Terbutaline sulfate should not be used for tocolysis. Serious adverse >reactions may occur after administration ofterbutaline sulfate to women >in labor. In the >mother, theseinclude increased heart rate, transient >hyperglycemia,hypokalemia, cardiac arrhythmias,pulmonary edema, >andmyocardial ischemia. Increased >fetal heart rate andneonatal hypoglycemia may occur as a result of >maternal administration. > >DOSAGE AND ADMINISTRATION > >Ampuls should be used only for subcutaneous administration and not >intravenous infusion. Sterility and >accurate dosing cannot be assured if the ampuls are >not used inaccordance with DOSAGE AND ADMINISTRATION.

Wow. I never read the package insert. Didn't realize they were this strong against it. Is this present on the PO version as well? (note: I do NOT use PO terbutaline!!)

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