Re: Post-menopausal cyst

From: art fougner, md (evsono@pipeline.com)
Sat Jul 15 21:38:15 2000


Joanne -

last year we had the flip side case. a 1 yr postmnopausal 52 y/o woman was referred for an ultrasound with a bordeline levated ( ~ 50 ) CA 125 ordered reluctantly by her gyn because she insisted. the ultrasound confirmed the pelvic exam - no abnormal masses. because a recent publication on screening CA 125 's in The Lancet had suggested a 3 month repeat f the CA 125 in those cases, that was suggested to the referring gyn. The patient, however, chose not to wait and got the test done 2 mos later. The CA 125 was 1000! repeat sonogram again failed to demonstrate abnrmal adnexal mass. However, this time a fair amount of free pelvic fluid was noted. further w/u failed to explain the new onset free pelvic fluid with CA125 elevation and the patient was explored, at which time disseminated intraperitoneal carcinomatosis was found - diffuse implants of papillary serous tumor without a discrete primary mass. in fact, aside from surface studding, the ovaries were quite nl in appearance. so perhaps the CA 125 should not be discarded so quickly. we still have so far to go in the diagnosis and treatment of ovarian cancer. perhaps with the advances in genomics, better markers can be found to help better stratify risks.

art

At Sat, 15 Jul 2000, Joanne Bulley, MD wrote: >
>Well, I have had the experience of one patient 50-ish with a multicystic
>5 or so cm ovary and NORMAL CA-125 on the day of her laparotomy (this is
>about 10 years ago) - die of her ovarian cancer within 2 years of
>daignosis. I do not use CA-125 as part of my "flow chart"...
>
>Joanne
>
>a series begins with one case...
>
>At Sat, 15 Jul 2000, Steve & Eryl Raymond wrote:
>>
>>I concur with the suggestion about doing Ca-125. There was a
>>paper presented at the International Scientific Meeting of the
>>RCOG last year which came from the UK suggesting a flow chart
>>for screening, and suggested that with U/S first followed by Ca-125
>>if anything found, there would be aan almost 100% pickup rate.
>
>--
>Joanne Bulley, MD
>Keene, NH, USA
>

--
art fougner, md

A series of 1000 cases begins with but a single anecdote.





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