Re: ? HELLP Syndrome

From: james connerth (babydoc@apex.net)
Wed Jul 5 11:51:22 2000


Agree with d/c mag and KEEP in hosp-karyotype great --is this "mirror syndrome"-may be seen with aneuploidy /severe RH-hydrops--mom looks like baby-SICK???

DoctorJoe@aol.com wrote:

> In a message dated 7/5/0 10:00:17 AM, you wrote:
>
> <<All right, I really need help on this one y'all.
>
> 28 yo presents at 21.5 weeks with severe headache, epigastric pain and mild
> shortness of breath. Found to have elevated liver function tests, 25 pound
> weight gain in 3 days. Coags, urine protein, renal function, cardiac echo,
> uric acid, TSH, autoimmune and antiphospholipid work-up all normal.
> Ultrasound shows viable AGA fetus, no evidence of molar element
>
> Hospitalized and started on mag sulfate. Over the course of the next week,
> the edema resolved and the liver function returned to normal and has remained
> such. The patient feels great except residual pain from the markedly severe
> pedal edema she had. Fetus continues to look good.
>
> Now what to do:
>
> -Stop the mag and send her home?
>
> -Keep her on the mag, in the hospital and wait for the hammer to drop>>
>
> Would wonder about a quick karyotype... STILL worried about triploidy, since
> his is WAY early for preeclampsia in its usual presentation. Maybe a CVS
> (which CAN be done on a "mature" placenta, right? Esp. if you're looking a
> chromosome numbers, rather than weird deletions etc.. which take more time.)
>
> It's fairly characteristic that in preeclampsia, bed rest will TEMPORARILY
> make the syndrome get "better," but it always returns. I'd be scared to let
> her go home like this, especially with the epigastric pain and elevated liver
> functions. If she goes home, she could come back with seizures and/or
> ruptured liver. So I'd vote to keep her so the hammer can drop in the
> hospital under observation.
>
> Joe P.





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