Re: FYI [Fwd: Oral sex and pre-eclampsia]
From: art fougner, md (evsono@pipeline.com)
Wed May 3 11:08:42 2000
does anyone else find this hard to swallow?
sorry - couldn't resist. :)
art
At Tue, 02 May 2000, Mark Jutras wrote:
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>Date: Tue, 2 May 2000 15:53:49 +0800
>To: spermail@cleo.murdoch.edu.au
>From: Dr Jim Cummins <cummins@central.murdoch.edu.au>
>Subject: Oral sex and pre-eclampsia
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>(I kid you not!)
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><fontfamily><param>Geneva</param>Koelman CA, Coumans ABC, Nijman HW,
>Doxiadis IIN, Dekker GA, Claas FHJ
>
>Correlation between oral sex and a low incidence of preeclampsia: a
>role for soluble HLA in seminal fluid?
>
>Journal of Reproductive Immunology 2000 Mar;46(2):155-166
>
>I quote fromthe abstract:
>
>The involvement of immune mechanisms in the aetiology of preeclampsia
>is often suggested. Normal pregnancy is thought to be associated with a
>state of tolerance to the foreign antigens of the fetus, whereas in
>preeclamptic women this immunological tolerance might be hampered. The
>present study shows that oral sex and swallowing sperm is correlated
>with a diminished occurrence of preeclampsia which fits in the existing
>idea that a paternal factor is involved in the occurrence of
>preeclampsia. Because pregnancy has many similarities with
>transplantation, we hypothesize that induction of allogeneic tolerance
>to the paternal HLA molecules of the fetus may be crucial. Recent data
>suggest that exposure, and especially oral exposure to soluble HLA
>(sHLA) or HLA derived peptides can lead to transplantation tolerance.
>Similarly, sHLA antigens, that are present in the seminal plasma, might
>cause tolerance in the mother to paternal antigens. In order to test
>whether this indeed may be the case, we investigated whether sHLA
>antigens are present in seminal plasma. Using a specific ELISA we
>detected sHLA class I molecules in seminal plasma. The level varied
>between individuals and was related to the level in plasma. Further
>studies showed that these sHLA class I molecules included classical HLA
>class I alleles. such as sHLA-A2. -B7. -B51. -B35 and sHLA-A9.
>Preliminary data show lower levels of sHLA in seminal plasma in the
>preeclampsia group, although not significantly different from the
>control group. An extension of the present study is necessary to verify
>this hypothesis.
>
>Claas FHJ Leiden Univ, Med Ctr, Dept Immunohematol & Blood Bank POB
>9600 NL-2300 RC Leiden Netherlands
>
></fontfamily>
>
>Dr Jim Cummins, Anatomy, Division of Veterinary and Biomedical
>Sciences,
>
>Murdoch University, GPO Box S1400
>
>Perth, Western Australia 6849
>
>Tel +61-8-9360 2668: Fax +61-8-9310 4144: E-fax +1 -413-431-6357.
>
>E mail cummins@central.murdoch.edu.au
>
>http://numbat.murdoch.edu.au/spermatology/spermhp.html
>
>God: "An inordinate fondness for beetles" - Haldane
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--
art fougner, md
A series of 1000 cases begins with but a single anecdote.
